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1. WO2020113061 - COMPOSITIONS AND METHODS FOR ENHANCING SPERM FUNCTION

Publication Number WO/2020/113061
Publication Date 04.06.2020
International Application No. PCT/US2019/063687
International Filing Date 27.11.2019
IPC
A61B 17/43 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
BDIAGNOSIS; SURGERY; IDENTIFICATION
17Surgical instruments, devices or methods, e.g. tourniquets
42Gynaecological or obstetrical instruments or methods
425for reproduction or fertilisation
43for artificial insemination
C12N 5/073 2010.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
07Animal cells or tissues
071Vertebrate cells or tissues, e.g. human cells or tissues
073Embryonic cells or tissues; Foetal cells or tissues
CPC
C12N 5/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
C12N 5/061
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
06Animal cells or tissues; Human cells or tissues
0602Vertebrate cells
0608Germ cells
061Sperm cells, spermatogonia
Applicants
  • OHANA BIOSCIENCES, INC. [US]/[US]
Inventors
  • SEYB, Kathleen Inez
  • SOLANO, Felipe A. Navarrete
  • FURFINE, Eric Steven
  • PERLEY, Christopher R.
  • SANTOS, Nicolas Da Silva
Agents
  • KOYFMAN, Hannah, R.
Priority Data
16/282,20421.02.2019US
16/282,21721.02.2019US
16/282,22421.02.2019US
62/773,43330.11.2018US
62/773,44030.11.2018US
62/773,44830.11.2018US
62/773,45330.11.2018US
62/773,46230.11.2018US
62/773,47130.11.2018US
62/914,80314.10.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMPOSITIONS AND METHODS FOR ENHANCING SPERM FUNCTION
(FR) COMPOSITIONS ET MÉTHODES POUR AMÉLIORER LA FONCTION SPERMATIQUE
Abstract
(EN)
The disclosure provides, inter alia, methods of improving sperm function and related methods of fertilization, together with preparations of activated or potentiated sperm. The methods provided by the disclosure, in some embodiments entail energy depletion with subsequent staged reintroduction of different energy sources. The disclosure additionally provides articles of manufacture suitable for performing the methods provided by the invention. The invention provides kits for separating sperm and for processing and preparing sperm for, in some embodiments, IVF or IUI. Also provided are nutrient free reagents useful preparing sperm.
(FR)
L'invention concerne, entre autres, des procédés d'amélioration de la fonction spermatique et des procédés associés de fertilisation, ainsi que des préparations de sperme activé ou potentialisé. Les procédés selon l'invention comprennent, dans certains modes de réalisation, un épuisement de l'énergie avec une réintroduction étagée subséquente de différentes sources d'énergie. L'invention concerne également des articles manufacturés appropriés pour mettre en oeuvre les procédés selon l'invention. L'invention concerne des kits pour la séparation spermatique et le traitement et la préparation de sperme pour, dans certains modes de réalisation, la FIV ou l'IIU. L'invention concerne également des réactifs exempts de nutriments utiles pour préparer le sperme.
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