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1. WO2020113059 - BIOMEMBRANE-COVERED NANOPARTICLES (BIONPS) FOR DELIVERING ACTIVE AGENTS TO STEM CELLS

Publication Number WO/2020/113059
Publication Date 04.06.2020
International Application No. PCT/US2019/063685
International Filing Date 27.11.2019
IPC
A61K 47/46 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
A61P 31/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61P 31/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10Antimycotics
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
B01J 13/02 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
13Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
02Making microcapsules or microballoons
CPC
A61K 47/46
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
46Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
A61P 31/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
04Antibacterial agents
A61P 31/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
10Antimycotics
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
B01J 13/04
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
13Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
02Making microcapsules or microballoons
04by physical processes, e.g. drying, spraying
Applicants
  • PAPOUTSAKIS, Eleftherios, T. [US]/[US]
  • DAY, Emily [US]/[US]
  • WINTER, Erica [US]/[US]
  • HARRIS, Jenna [US]/[US]
  • KAO, Chen-Yuan
  • DAS, Samik [US]/[US]
Inventors
  • PAPOUTSAKIS, Eleftherios, T.
  • DAY, Emily
  • WINTER, Erica
  • HARRIS, Jenna
  • KAO, Chen-Yuan
  • DAS, Samik
Agents
  • ZHONG, Ling
Priority Data
62/772,31128.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BIOMEMBRANE-COVERED NANOPARTICLES (BIONPS) FOR DELIVERING ACTIVE AGENTS TO STEM CELLS
(FR) NANOPARTICULES RECOUVERTES DE BIOMEMBRANE (BIONP) POUR L'ADMINISTRATION DE PRINCIPES ACTIFS À DES CELLULES SOUCHES
Abstract
(EN)
The present invention provides bio-nanoparticles (BioNPs) for delivering an active agent into hematopoietic stem & progenitor cells (HSPCs). Each BioNP comprises a core and a biological membrane covering the core, which comprises the active agent and a polymer. The biological membrane comprises a phospholipid bilayer and one or more surface proteins of a megakaryocyte (Mk). The active agent remains active after being delivered into the HSPC. Also provided are methods for preparing the BioNPs and uses of the BioNPs for targeted delivery of an active agent into HSPCs and/or treating or preventing a disease or condition in a subject in need thereof.
(FR)
La présente invention concerne des bio-nanoparticules (BioNP) pour administrer un principe actif dans des cellules souches hématopoïétiques & progénitrices (HSPC). Chaque BioNP comprend un cœur et une membrane biologique recouvrant le cœur, qui comprend le principe actif et un polymère. La membrane biologique comprend une bicouche phospholipidique et une ou plusieurs protéines de surface d'un mégacaryocyte (Mk). Le principe actif reste actif après avoir été administré dans les HSPC. L'invention concerne également des procédés de préparation des BioNP et des utilisations des BioNP pour l'administration ciblée d'un principe actif dans des HSPC et/ou pour traiter ou prévenir une maladie ou un problème médical chez un sujet en ayant besoin.
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