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1. WO2020113047 - ANTIBODIES CONJUGATED WITH ACTINIUM-225 AND ACTINIUM-227, AND RELATED COMPOSITIONS AND METHODS

Publication Number WO/2020/113047
Publication Date 04.06.2020
International Application No. PCT/US2019/063668
International Filing Date 27.11.2019
IPC
A61K 51/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier
04Organic compounds
08Peptides, e.g. proteins
10Antibodies or immunoglobulins; Fragments thereof
A61K 39/44 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
44Antibodies bound to carriers
A61K 103/40 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
103Radioactive metals
40Actinides
CPC
A61K 39/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
44Antibodies bound to carriers
A61K 51/1027
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
08Peptides, e.g. proteins ; , carriers being peptides, polyamino acids, proteins
10Antibodies or immunoglobulins; Fragments thereof ; , the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody
1003not used, see subgroups
1027against receptors, cell-surface antigens, cell-surface determinants
A61K 51/1093
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
08Peptides, e.g. proteins ; , carriers being peptides, polyamino acids, proteins
10Antibodies or immunoglobulins; Fragments thereof ; , the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody
1093conjugates with carriers being antibodies
A61K 51/1096
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
51Preparations containing radioactive substances for use in therapy or testing in vivo
02characterised by the carrier ; , i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
04Organic compounds
08Peptides, e.g. proteins ; , carriers being peptides, polyamino acids, proteins
10Antibodies or immunoglobulins; Fragments thereof ; , the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody
1093conjugates with carriers being antibodies
1096radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
Applicants
  • ACTINIUM PHARMACEUTICALS, INC. [US]/[US]
Inventors
  • LUDWIG, Dale
  • O'LOUGHLIN, Steve
  • PATEL, Vimal
  • RAY, Nitya
  • SETH, Sandesh
Agents
  • MORRISON, Alan, J.
Priority Data
62/773,23430.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTIBODIES CONJUGATED WITH ACTINIUM-225 AND ACTINIUM-227, AND RELATED COMPOSITIONS AND METHODS
(FR) ANTICORPS CONJUGUÉS À L'ACTINIUM 225 ET L'ACTINIUM 227, COMPOSITIONS ET PROCÉDÉS ASSOCIÉS
Abstract
(EN)
This invention provides a compositions of matter comprising a therapeutic protein population (such as a HuM195 antibody population) wherein (a) each therapeutic protein in the population is conjugated to one or more actinium atoms, (b) each actinium atom is either 227Ac or 225Ac, and (c) the molar ratio of 227Ac to 225Ac in the composition is at least 1:1, This invention also provides related synthetic compositions and methods, as well as methods for treating hematologic malignancies.
(FR)
La présente invention concerne une composition de matière comprenant une population de protéines thérapeutiques (telle qu'une population d'anticorps HuM195) dans laquelle (a) chaque protéine thérapeutique de la population est conjuguée à un ou plusieurs atomes d'actinium, (b) chaque atome d'actinium est soit 227Ac, soit 225Ac, et (c) le rapport molaire de 227Ac sur 225Ac dans la composition est d'au moins 1 : 1. La présente invention concerne également des compositions et des procédés synthétiques apparentés, ainsi que des procédés de traitement de malignités hématologiques.
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