Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020113044 - METHOD AND COMPOSITION FOR REMOVING UREMIC TOXINS

Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

[ EN ]

WHAT IS CLAIMED IS:

1. A sorbent comprising a titanium-glyoxal complex and a porous support material.

2. The sorbent of claim 1, wherein the porous support material comprises activated carbon, graphene, graphene oxide, silicon, porous silicon, or a combination thereof.

3. The sorbent of claim 1 or 2, wherein the titanium-glyoxal complex comprises titanium-crosslinked hydrated glyoxal moieties.

4. The sorbent of claim 1 or 2, wherein the titanium-glyoxal complex is formed by reacting hydrated glyoxal with titanium ions.

5. The sorbent of claim 1 or 2, wherein the titanium-glyoxal complex has a structure comprising a molecule of formula I, formula II, formula III, formula IV, or a combination thereof:


6. The sorbent of claim 1 or 2, wherein the titanium-glyoxal complex is associated with, adhered to, adsorbed on, coated on, and/or immobilized on the porous support material.

7. The sorbent of claim 1 or 2, wherein the titanium-glyoxal complex is present in pores of the porous support material.

8. The sorbent of claim 1 or 2, having a urea capacity of greater than about 50 mg urea/g sorbent, such as greater than about 60 mg/g, greater than about 70 mg/g, greater than about 75 mg/g, greater than about 80 mg/g, greater than about 90 mg/g, about 50 mg/g to about 200 mg/g, about 50 mg/g to about 150 mg/g, about 50 mg/g to about 100 mg/g, about 60 mg/g to about 100 mg/g, about 70 mg/g to about 90 mg/g, about 75 mg/g to about 85 mg/g, and/or about 80 mg/g.

9. The sorbent of claim 1 or 2, wherein the molar ratio of titanium to glyoxal is about 1 :4.

10. A sorbent cartridge comprising the sorbent of claim 1 or 2.

11. The sorbent cartridge of claim 10, wherein the sorbent cartridge is free of an

immobilized urease layer.

12. The sorbent cartridge of claim 10, wherein total content of active urease in the cartridge is less than about 5 wt. % based on total immobilized weight portion of cartridge contents.

13. The sorbent cartridge of claim 10, further comprising dialysate fluid which

communicates with the sorbent.

14. The sorbent cartridge of claim 10, further comprising a layer comprising titanium oxide, hydrous titanium dioxide, and/or titanium phosphate.

15. A method comprising passing a fluid comprising urea though the sorbent of claim 1 and/or through the sorbent cartridge of claim 10, thereby binding urea to the titanium-glyoxal complex.

16. An apparatus for conducting dialysis comprising the sorbent cartridge of claim 10, and a dialyzer in fluid communication with the sorbent cartridge, wherein spent dialysis fluid passes from the dialyzer to and through the sorbent cartridge.

17. The apparatus of claim 16, wherein the dialyzer is in fluid communication with the blood of a patient.

18. A dialysis system comprising the sorbent cartridge of claim 10 and a source of spent dialysis fluid, wherein the source of spent dialysis fluid is in fluid communication with the sorbent cartridge and the spent dialysis fluid passes to and through the sorbent cartridge.

19. A method of making a sorbent for binding urea, comprising:

(i) combining glyoxal, a titanium ion source, and a solvent to provide a mixture comprising a titanium-glyoxal complex;

(ii) adding activated carbon to the mixture to provide a treated activated carbon;

(iii) separating the solvent from the treated activated carbon;

(iv) washing the treated activated carbon to provide a washed treated activated carbon; and

(v) drying the washed treated activated carbon to provide a sorbent for binding urea.

20. The method of claim 26, wherein the titanium ion source is selected from the group consisting of titanium tetrachloride, titanium (II) chloride, titanium (III) chloride, titanium oxychloride, and combinations thereof.