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1. WO2020112970 - BW6 SPECIFIC CAR DESIGNED TO PROTECT TRANSPLANTED TISSUE FROM REJECTION

Publication Number WO/2020/112970
Publication Date 04.06.2020
International Application No. PCT/US2019/063564
International Filing Date 27.11.2019
IPC
A61K 39/385 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
385Haptens or antigens, bound to carriers
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/04 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C07K 14/76 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
76Albumins
CPC
A61K 39/385
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
385Haptens or antigens, bound to carriers
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/04
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
04Immunostimulants
C07K 14/7051
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
705Receptors; Cell surface antigens; Cell surface determinants
70503Immunoglobulin superfamily
7051T-cell receptor (TcR)-CD3 complex
C07K 2319/03
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
01containing a localisation/targetting motif
03containing a transmembrane segment
Applicants
  • THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA [US]/[US]
  • ONE LAMBDA, INC. [US]/[US]
Inventors
  • RILEY, James L.
  • ELLIS, Gavin
  • LEE, Jar-How
  • SHIH, Neng Jen Remi
  • NONG, Thoa
Agents
  • DOYLE, Kathryn
  • LANDRY, Brian
  • SILVA, Domingos J.
  • SIMPSON, Mark D.
  • CROTTY, Justin
  • YOUNG, Jacque
  • BROWNING, Elizabeth
  • OSTROVSKY, Dennis
  • WRIGHT, Christopher
Priority Data
62/773,27430.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BW6 SPECIFIC CAR DESIGNED TO PROTECT TRANSPLANTED TISSUE FROM REJECTION
(FR) CAR SPÉCIFIQUE DE BW6 CONÇU POUR PROTÉGER UN TISSU GREFFÉ CONTRE LE REJET
Abstract
(EN)
The present invention includes compositions and methods for an HLA-BW6 specific chimeric antigen receptor (CAR). In certain embodiments the HLA-BW6 specific CAR is expressed on a T regulatory cell. In certain embodiments, the HLA-BW6 specific CAR protects transplanted tissue from rejection.
(FR)
La présente invention concerne des compositions et des méthodes pour un récepteur d'antigène chimérique (CAR) spécifique de HLA-BW6. Dans certains modes de réalisation, le CAR spécifique HLA-BW6 est exprimé sur un lymphocyte T régulateur. Dans certains modes de réalisation, le CAR spécifique HLA-BW6 protège le tissu greffé contre le rejet.
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