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1. WO2020112935 - METHODS OF TREATING DISEASE WITH DICHLORPHENAMIDE

Publication Number WO/2020/112935
Publication Date 04.06.2020
International Application No. PCT/US2019/063507
International Filing Date 27.11.2019
IPC
A61K 31/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
18Sulfonamides
C07C 311/15 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
311Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
CPC
A61K 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
18Sulfonamides
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
Applicants
  • STRONGBRIDGE DUBLIN LIMITED [IE]/[US]
  • COHEN, Fredric [US]/[US]
Inventors
  • COHEN, Fredric
Agents
  • STEVENS, Lauren
Priority Data
16/205,60230.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF TREATING DISEASE WITH DICHLORPHENAMIDE
(FR) MÉTHODES DE TRAITEMENT D'UNE MALADIE À L'AIDE DE DICHLORPHÉNAMIDE
Abstract
(EN)
Provided herein is a method for administering dichlorphenamide, or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the subject is also being administered a therapeutically effective amount of a drug chosen from a P-gp substrate, BCRP substrate, OAT2 substrate, OAT4 substrate, OCT1 substrate, MATE1 substrate, MATE2-K substrate, and combinations thereof. The method comprises administering to the subject a therapeutically effective amount of dichlorphenamide, or a pharmaceutically acceptable salt thereof. The therapeutically effective amount of the drug is not adjusted relative to a subject who is being administered the drug and who is not being administered dichlorphenamide.
(FR)
La présente invention concerne un procédé d'administration de dichlorphénamide, ou d'un sel pharmaceutiquement acceptable de celui-ci, à un sujet en ayant besoin, une quantité thérapeutiquement efficace d'un médicament choisi parmi un substrat P-gp, un substrat BCRP, un substrat OAT2, un substrat OAT4, un substrat OCT1, un substrat MATE1, un substrat MATE2-K et des combinaisons de ceux-ci étant également administrée au sujet. Le procédé consiste à administrer au sujet une quantité thérapeutiquement efficace de dichlorphénamide ou d'un sel pharmaceutiquement acceptable de celui-ci. La quantité thérapeutiquement efficace du médicament n'est pas ajustée par rapport à un sujet auquel le médicament est administré et auquel le dichlorphénamide n'est pas administré.
Also published as
Latest bibliographic data on file with the International Bureau