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1. WO2020112934 - METHODS OF TREATING DISEASE WITH DICHLORPHENAMIDE

Publication Number WO/2020/112934
Publication Date 04.06.2020
International Application No. PCT/US2019/063505
International Filing Date 27.11.2019
IPC
A61K 31/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
18Sulfonamides
C07C 311/15 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
311Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
CPC
A61K 31/18
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
16Amides, e.g. hydroxamic acids
18Sulfonamides
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
G01N 33/5014
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
5005involving human or animal cells
5008for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
5014for testing toxicity
Applicants
  • STRONGBRIDGE DUBLIN LIMITED [IE]/[US]
  • COHEN, Fredric [US]/[US]
Inventors
  • COHEN, Fredric
Agents
  • STEVENS, Lauren
Priority Data
16/201,41027.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF TREATING DISEASE WITH DICHLORPHENAMIDE
(FR) MÉTHODES DE TRAITEMENT D'UNE MALADIE AVEC DU DICLOFÉNAMIDE
Abstract
(EN)
Provided herein are methods for administering dichlorphenamide, or a pharmaceutically acceptable salt thereof, to a subject in need thereof, wherein the subject is also being administered an organic anion transporter-1 (OAT1) substrate to treat an associated disease or disorder. The method comprises administering to the subject a therapeutically effective amount of dichlorphenamide, or a pharmaceutically acceptable salt thereof, and monitoring the subject for signs and symptoms of toxicity and clinical response associated with the OAT1 substrate.
(FR)
L'invention concerne des méthodes d'administration de diclofénamide, ou d'un sel pharmaceutiquement acceptable de celui-ci, à un sujet en ayant besoin, un substrat transporteur d'anions organiques 1 (OAT1) étant également administré au sujet pour traiter une maladie ou un trouble associé. La méthode consiste à administrer au sujet une quantité thérapeutiquement efficace de diclofénamide, ou d'un sel pharmaceutiquement acceptable de celui-ci, et à surveiller les signes et les symptômes de toxicité et de réponse clinique associés au substrat OAT1 chez le sujet.
Also published as
Latest bibliographic data on file with the International Bureau