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1. WO2020112889 - METHODS FOR TREATING DYSREGULATED LIPID METABOLISM

Publication Number WO/2020/112889
Publication Date 04.06.2020
International Application No. PCT/US2019/063427
International Filing Date 26.11.2019
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
A61P 3/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
A61P 25/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
CPC
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
C07K 16/2803
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
C07K 2317/75
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
75Agonist effect on antigen
Applicants
  • DENALI THERAPEUTICS INC. [US]/[US]
Inventors
  • ASTARITA, Giuseppe
  • DI PAOLO, Gilbert
  • LIN, Kai Lin
  • MONROE, Kathryn M.
  • NUGENT, Alicia A.
  • VAN LENGERICH, Bettina
Agents
  • KRUEGER, Katherine A.D.
  • HARRIS, Robert J.
  • VIKSNINS, Ann S.
  • MALEN, Peter L.
  • MICKELSON, John W.
  • PADYS, Danny J.
  • ANDRUS, Alex
  • NIU, Lin
Priority Data
62/771,45626.11.2018US
62/817,95513.03.2019US
62/890,50622.08.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS FOR TREATING DYSREGULATED LIPID METABOLISM
(FR) PROCÉDÉS DE TRAITEMENT DU MÉTABOLISME LIPIDIQUE DÉRÉGULÉ
Abstract
(EN)
Certain embodiments described herein provide a method for treating dysregulated lipid metabolism and/or inflammation in a mammal in need thereof, comprising administering to the mammal an effective amount of an agonist anti-triggering receptor expressed on myeloid cells 2 (TREM2) antibody.
(FR)
Certains modes de réalisation de la présente invention concernent un procédé de traitement du métabolisme lipidique et/ou de l'inflammation dérégulés chez un mammifère en ayant besoin, comprenant l'administration au mammifère d'une quantité efficace d'un récepteur anti-déclenchement agoniste exprimé sur l'anticorps de cellules myéloïdes 2 (TREM2).
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