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1. WO2020112883 - INHIBITION OF LYSINE DEMETHYLASE 1 (LSD1) INDUCES DIFFERENTIATION OF HAIR CELLS

Publication Number WO/2020/112883
Publication Date 04.06.2020
International Application No. PCT/US2019/063418
International Filing Date 26.11.2019
IPC
A61K 31/47 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
CPC
A61K 31/47
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
47Quinolines; Isoquinolines
Applicants
  • MASSACHUSETTS EYE AND EAR INFIRMARY [US]/[US]
Inventors
  • EDGE, Albert
  • GUNEWARDENE, Niliksha
Agents
  • XING, Liujing
  • DEYOUNG, Janice Kugler
Priority Data
62/773,96530.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITION OF LYSINE DEMETHYLASE 1 (LSD1) INDUCES DIFFERENTIATION OF HAIR CELLS
(FR) INHIBITION DE LA LYSINE DÉMÉTHYLASE 1 (LSD1), INDUISANT LA DIFFÉRENCIATION DES CELLULES CILIÉES
Abstract
(EN)
Methods for the generation of sensorineural hair cells, and more particularly to the use of epigenetic modulation of Atoh1 expression using a combination of Histone Lysine Demethylase (KDM) inhibitors and Wnt activators to generate sensorineural hair cells.
(FR)
L'invention concerne des méthodes de génération de cellules ciliées neurosensorielles, et plus particulièrement l'utilisation de la modulation épigénétique de l'expression d'Atoh1 à l'aide d'une combinaison d'inhibiteurs d'Histone Lysine Déméthylase (KDM) et d'activateurs Wnt pour générer des cellules ciliées sensorielles.
Latest bibliographic data on file with the International Bureau