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1. WO2020112872 - METHODS OF TREATING WHSC1-OVEREXPRESSING CANCERS BY INHIBITING SETD2

Publication Number WO/2020/112872
Publication Date 04.06.2020
International Application No. PCT/US2019/063405
International Filing Date 26.11.2019
IPC
A61K 31/7076 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7076containing purines, e.g. adenosine, adenylic acid
A61K 31/7088 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
A61K 31/713 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
713Double-stranded nucleic acids or oligonucleotides
A61K 38/46 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
CPC
A61K 31/7076
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7042Compounds having saccharide radicals and heterocyclic rings
7052having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706containing six-membered rings with nitrogen as a ring hetero atom
7064containing condensed or non-condensed pyrimidines
7076containing purines, e.g. adenosine, adenylic acid
A61K 31/7088
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
A61K 31/713
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
713Double-stranded nucleic acids or oligonucleotides
A61K 38/46
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
Applicants
  • EPIZYME, INC. [US]/[US]
Inventors
  • THOMENIUS, Michael
  • COSMOPOULOS, Katherine, Louise
  • TOTMAN, Jennifer, Anne
Agents
  • COVERT, John, M.
  • STERNE, Robert Greene
  • GOLDSTEIN, Jorge A.
  • DURKIN, Tracy-Gene G.
  • ESMOND, Robert W.
  • CIMBALA, Michele A.
  • FEATHERSTONE, Donald J.
  • RAY, Michael B.
  • MILLONIG, Robert C.
  • LEE, Michael Q.
  • SOKOHL, Robert E.
  • LONGSWORTH, Gaby L.
  • STEFFE, Eric K.
  • ELLISON, Eldora L.
  • SHEA JR., Timothy J.
  • BANOWIT, Donald R.
  • EISENBERG, Jason D.
  • HELVEY, Jeffrey T.
  • RYGIEL, Mark W.
  • JACKMAN, Peter A.
  • BODENSTEIN, Matthew
  • WRIGHT, Jon E.
  • YONAN, Daniel E.
  • HOLOUBEK, Michelle K.
  • SPECHT, Michael D.
  • HICKS, Ross G.
  • CALVO, Paul A.
  • GILLENTINE, Marsha Rose
  • COLLER III, Richard D.
  • BEZOS, Salvador M.
  • TUMINARO, Jonathan
  • STERLING, Deborah A.
  • MUTSCHELKNAUS, Joseph
  • PICKARD, Byron L.
  • FRUEAUF, Jeremiah B.
  • NANNENGA-COMBS, Bonnie
  • KIM, Ji Eun
  • DESAI, Nirav N.
  • CAMARCE, Christian
  • CONKLIN, Kyle
  • POWERS III, R. Wilson
  • GAJEWSKI, Daniel
  • FITZSIMMONS, Jason A.
  • KENTON JR., Lestin L.
  • BLOCK, Daniel S.
  • RICHARDSON, Ryan C.
  • BEMBEN, Richard M.
Priority Data
62/773,77030.11.2018US
62/857,12004.06.2019US
62/886,88014.08.2019US
PCT/US2019/04656914.08.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS OF TREATING WHSC1-OVEREXPRESSING CANCERS BY INHIBITING SETD2
(FR) PROCÉDÉS DE TRAITEMENT DE CANCERS À SUREXPRESSION DE WHSC1 PAR INHIBITION DE SETD2
Abstract
(EN)
The present disclosure provides methods and pharmaceutical compositions for treating or slowing the progression of cancers that overexpress the histone methyltransferase WHSC1, e.g., t(4;14) multiple myeloma, by administering to a subject in need thereof a therapeutically effective amount of an inhibitor of the histone methyltransferase, SETD2.
(FR)
La présente invention concerne des procédés et des compositions pharmaceutiques, destinés à traiter ou ralentir la progression de cancers qui surexpriment l'histone méthyltransférase WHSC1, par ex., le myélome multiple t(4;14) par administration à un sujet en ayant besoin d'une quantité thérapeutiquement efficace d'un inhibiteur de l'histone méthyltransférase, SETD2.
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