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1. WO2020112868 - COMBINATION THERAPY OF PEPTIDOMIMETIC MACROCYCLES

Publication Number WO/2020/112868
Publication Date 04.06.2020
International Application No. PCT/US2019/063397
International Filing Date 26.11.2019
IPC
C07K 7/56 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
50Cyclic peptides containing at least one abnormal peptide link
54with at least one abnormal peptide link in the ring
56the cyclisation not occurring through 2,4-diamino-butanoic acid
A61K 38/08 2019.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
A61K 38/15 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
15Depsipeptides; Derivatives thereof
CPC
A61K 38/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
08Peptides having 5 to 11 amino acids
A61K 38/15
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
15Depsipeptides; Derivatives thereof
C07K 7/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
50Cyclic peptides containing at least one abnormal peptide link
54with at least one abnormal peptide link in the ring
56the cyclisation not occurring through 2,4-diamino-butanoic acid
Applicants
  • AILERON THERAPEUTICS, INC. [US]/[US]
Inventors
  • GUERLAVAIS, Vincent
  • ANNIS, David Allen
Agents
  • CHOW, Carmen
Priority Data
62/773,54030.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) COMBINATION THERAPY OF PEPTIDOMIMETIC MACROCYCLES
(FR) POLYTHÉRAPIE AYANT RECOURS À DES MACROCYCLES PEPTIDOMIMÉTIQUES
Abstract
(EN)
The present disclosure describes the synthesis of peptidomimetic macrocycles and methods of using peptidomimetic macrocycles to treat a condition. The present disclosure also describes methods of using peptidomimetic macrocycles in combination with at least one additional pharmaceutically-active agent for the treatment of a condition, for example, cancer.
(FR)
La présente invention concerne la synthèse de macrocycles peptidomimétiques et des méthodes d'utilisation de macrocycles peptidomimétiques pour traiter une affection. La présente invention concerne également des méthodes d'utilisation de macrocycles peptidomimétiques en association avec au moins un agent pharmaceutiquement actif supplémentaire pour le traitement d'une affection, par exemple le cancer.
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