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1. WO2020112788 - DRUG DELIVERY AND BIOMARKER ACCESS DEVICES

Note: Text based on automatic Optical Character Recognition processes. Please use the PDF version for legal matters

[ EN ]

WHAT IS CLAIMED IS:

1. An implantable drug delivery and biomarker access device, comprising:

a first reservoir configured to be implanted between a scalp and skull of a patient, the first reservoir being naturally biased to be in an expanded configuration; a second reservoir configured to be implanted between the scalp and the skull of the patient, the first reservoir being naturally biased to be in an unexpanded configuration;

a first one-way valve disposed along a fluid connection between the first and second reservoirs, the first one-way valve oriented to allow fluid to flow from the first reservoir to the second reservoir and to prevent fluid from flowing from the second reservoir to the first reservoir;

a perfusion catheter extending from the second reservoir and in fluid communication therewith;

a return catheter extending from the first reservoir and in fluid communication therewith; and

a second one-way valve disposed along the return catheter, the second one way valve oriented to allow fluid to flow from the return catheter to the first reservoir and to prevent fluid from flowing from the first reservoir to the return catheter.

2. The implantable device of claim 1, further comprising a first flow control valve disposed along the perfusion catheter and configured to throttle or modulate fluid flow through the perfusion catheter.

3. The implantable device of claim 1 or 2, further comprising a second flow control valve disposed along the return catheter and configured to throttle or modulate fluid flow through the return catheter.

4. The implantable device of any one of claims 1 through 3, wherein at least a portion of the perfusion catheter and at least a portion of the return catheter are joined together as a dual lumen catheter.

5. The implantable device of claim 4, wherein at least a portion of the dual lumen

comprises the perfusion catheter located coaxially within the return catheter.

6. The implantable device of claim 5, wherein the dual lumen catheter includes wall fenestrations into the return catheter.

7. A method of delivering a drug into a brain parenchyma of a patient and accessing biomarkers from the brain parenchyma, the method comprising:

implanting the device of any one of claims 1 through 6 into the patient, wherein the first and second reservoirs are positioned between the scalp and the skull of the patient, and wherein the perfusion and return catheters extend into the brain parenchyma;

compressing the first reservoir such that a fluid in the first reservoir is caused to flow into the second reservoir;

allowing the fluid to flow out of the second reservoir and into the perfusion catheter as a result of the natural bias of the second reservoir to be in the unexpanded configuration, wherein at least some of the fluid that flows into the perfusion catheter exits from the perfusion catheter into the brain parenchyma; and

after compressing the first reservoir, allowing the first reservoir to re-expand as a result of the natural bias of the first reservoir to be in the expanded configuration, wherein at least some of the fluid from the brain parenchyma is drawn into the return catheter and flows from the return catheter into the first reservoir as a result of the re expansion of the first reservoir.

8. The method of claim 7, further comprising, after the at least some of the fluid from the brain parenchyma has flowed into the first reservoir, aspirating the fluid from the first reservoir.

9. The method of claim 8, wherein the aspirating is performed using a syringe through the scalp.