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1. WO2020112720 - T CELL-DIRECTED ANTI-CANCER VACCINES AGAINST COMMENSAL VIRUSES

Publication Number WO/2020/112720
Publication Date 04.06.2020
International Application No. PCT/US2019/063172
International Filing Date 26.11.2019
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 39/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
C07K 14/025 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
01DNA viruses
025Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
C07K 19/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
C12N 15/37 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
31Genes encoding microbial proteins, e.g. enterotoxins
33Genes encoding viral proteins
34Proteins from DNA viruses
37Papovaviridae, e.g. papillomaviruses, polyomavirus, SV40
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
C07K 14/025
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
005from viruses
01DNA viruses
025Papovaviridae, e.g. papillomavirus, polyomavirus, SV40, BK virus, JC virus
C07K 19/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
19Hybrid peptides
Applicants
  • THE GENERAL HOSPITAL CORPORATION [US]/[US]
Inventors
  • DEMEHRI, Shadmehr
Agents
  • DEYOUNG, Janice Kugler
  • FASSE, J. Peter
Priority Data
62/772,44328.11.2018US
62/831,69109.04.2019US
62/909,69802.10.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) T CELL-DIRECTED ANTI-CANCER VACCINES AGAINST COMMENSAL VIRUSES
(FR) VACCINS ANTICANCÉREUX DIRIGÉS CONTRE LES LYMPHOCYTES T CONTRE DES VIRUS COMMENSAUX
Abstract
(EN)
Immune-based approaches to treat and prevent skin cancer by boosting T cell immunity against commensal HPVs present on skin. Thus, provided herein are compositions comprising: (i) a plurality of antigenic peptides each comprising a sequence of 9-30 amino acids derived from proteins from commensal human papilloma viruses, (ii) a plurality of live or live attenuated commensal human papilloma viruses, (iii) a plurality of antigenic proteins from commensal human papilloma viruses, preferably in virus-like particles, and/or (iv) a plurality of nucleic acids encoding (a) a plurality of antigenic peptides, each comprising a sequence of 9-30 amino acids derived from proteins from commensal human papilloma viruses or (b) a plurality of antigenic proteins from commensal human papilloma viruses; and optionally a T cell adjuvant that increases T cell response to the antigenic peptides.
(FR)
La présente invention concerne des approches à base immunitaire pour traiter et prévenir le cancer de la peau par le renforcement de l'immunité des lymphocytes T contre les VPH commensaux présents sur la peau. Ainsi, la présente invention concerne des compositions comprenant : (i) une pluralité de peptides antigéniques comprenant chacun une séquence de 9 à 30 acides aminés dérivés de protéines provenant de papillomavirus humains commensaux, (ii) une pluralité de papillomavirus humains commensaux vivants ou vivants atténués, (iii) une pluralité de protéines antigéniques provenant de papillomavirus humains commensaux, de préférence dans des particules de type viral, et/ou (iv) une pluralité d'acides nucléiques codant pour (a) une pluralité de peptides antigéniques, comprenant chacun une séquence de 9 à 30 acides aminés dérivés de protéines provenant de papillomavirus humains commensaux ou (b) une pluralité de protéines antigéniques provenant de papillomavirus humains commensaux ; et éventuellement un adjuvant de lymphocytes T qui augmente la réponse des lymphocytes T aux peptides antigéniques.
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