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1. WO2020112706 - 7-, 8-, and 10-SUBSTITUTED AMINO TRIAZOLO QUINAZOLINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE

Publication Number WO/2020/112706
Publication Date 04.06.2020
International Application No. PCT/US2019/063146
International Filing Date 26.11.2019
IPC
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 487/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
08Bridged systems
C07D 487/18 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
12in which the condensed system contains three hetero rings
18Bridged systems
CPC
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
C07D 487/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
08Bridged systems
C07D 487/18
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
12in which the condensed system contains three hetero rings
18Bridged systems
Applicants
  • MERCK SHARP & DOHME CORP. [US]/[US]
  • ZHANG, Yonglian [CN]/[US] (US)
  • ALI, Amjad [US]/[US] (US)
  • CUMMING, Jared [US]/[US] (US)
  • DEMONG, Duane [US]/[US] (US)
  • DENG, Qiaolin [US]/[US] (US)
  • GRAHAM, Thomas, H. [US]/[US] (US)
  • HENNESSY, Elisabeth [US]/[US] (US)
  • LARSEN, Matthew, A. [US]/[US] (US)
  • LIU, Kun [US]/[US] (US)
  • LIU, Ping [US]/[US] (US)
  • MANSOOR, Umar Faruk [GB]/[US] (US)
  • PAN, Jianping [US]/[US] (US)
  • PLUMMER, Christopher, W. [US]/[US] (US)
  • SATHER, Aaron [US]/[US] (US)
  • SWAMINATHAN, Uma [IN]/[US] (US)
  • WANG, Huijun [US]/[US] (US)
Inventors
  • ZHANG, Yonglian
  • ALI, Amjad
  • CUMMING, Jared
  • DEMONG, Duane
  • DENG, Qiaolin
  • GRAHAM, Thomas, H.
  • HENNESSY, Elisabeth
  • LARSEN, Matthew, A.
  • LIU, Kun
  • LIU, Ping
  • MANSOOR, Umar Faruk
  • PAN, Jianping
  • PLUMMER, Christopher, W.
  • SATHER, Aaron
  • SWAMINATHAN, Uma
  • WANG, Huijun
Common Representative
  • MERCK SHARP & DOHME CORP.
Priority Data
62/774,06930.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 7-, 8-, and 10-SUBSTITUTED AMINO TRIAZOLO QUINAZOLINE DERIVATIVES AS ADENOSINE RECEPTOR ANTAGONISTS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE
(FR) DÉRIVÉS D'AMINO TRIAZOLO QUINAZOLINE À SUBSTITUTION EN POSITIONS 7, 8 ET 10 UTILISÉS EN TANT QU'ANTAGONISTES DU RÉCEPTEUR DE L'ADÉNOSINE, COMPOSITIONS PHARMACEUTIQUES ET LEUR UTILISATION
Abstract
(EN)
In its many embodiments, the present invention provides certain 7-, 8-, and 10-substituted amino triazolo quinazoline derivatives of Formula (I): or a pharmaceutically acceptable salt thereof, wherein ring A, R1, R2, and R4 are as defined herein, pharmaceutical compositions comprising one or more such compounds (alone and in combination with one or more other therapeutic agents), and methods for their preparation and use, alone and in combination with other therapeutic agents, as antagonists of A2a and/or A2b receptors, and their use in the treatment of a variety of diseases, conditions, or disorders that are mediated, at least in part, by the adenosine A2a receptor and/or the adenosine A2b receptor.
(FR)
Selon de nombreux modes de réalisation, la présente invention concerne certains dérivés d'amino triazolo quinazoline à substitution en positions 7, 8 et 10 de formule (I) : ou un sel pharmaceutiquement acceptable de ceux-ci, le cycle A, R1, R2 et R4 étant tels que définis dans la description, des compositions pharmaceutiques comprenant un ou plusieurs de ces composés (seuls et en combinaison avec un ou plusieurs autres agents thérapeutiques), et des procédés pour leur préparation et leur utilisation, seuls ou en combinaison avec d'autres agents thérapeutiques, utilisés en tant qu'antagonistes des récepteurs A2a et/ou A2b, et leur utilisation dans le traitement de diverses maladies, affections ou troubles à médiation, au moins en partie, par le récepteur A2a de l'adénosine et/ou le récepteur A2b de l'adénosine.
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