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1. WO2020112687 - HUMANIZED ANTIBODIES AGAINST C-KIT

Publication Number WO/2020/112687
Publication Date 04.06.2020
International Application No. PCT/US2019/063091
International Filing Date 25.11.2019
IPC
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
CPC
C07K 16/2803
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
C07K 2317/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
20characterized by taxonomic origin
24containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
C07K 2317/565
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
50characterized by immunoglobulin fragments
56variable (Fv) region, i.e. VH and/or VL
565Complementarity determining region [CDR]
C07K 2317/732
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
732Antibody-dependent cellular cytotoxicity [ADCC]
Applicants
  • FORTY SEVEN, INC. [US]/[US]
Inventors
  • LIU, Jie
  • SOMPALLI, Kavitha
Agents
  • LIEBESCHUETZ, Joe
  • CELLI, Rosemarie
  • SCHILLING, Stephen H.
  • SATHER, Susan
  • CHANG, Cindy
Priority Data
62/771,52626.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HUMANIZED ANTIBODIES AGAINST C-KIT
(FR) ANTICORPS HUMANISÉS DIRIGÉS CONTRE C-KIT
Abstract
(EN)
The invention provides antibodies specifically binding to c-Kit and methods of using such antibodies in stem cell replacement and treatment of cancer.
(FR)
L'invention concerne des anticorps se liant spécifiquement à c-Kit et des méthodes d'utilisation de tels anticorps dans le remplacement de cellules souches et le traitement du cancer.
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