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1. WO2020112642 - IMPROVED METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS WITH A DIPHTHERIA TOXIN-HUMAN INTERLEUKIN-3 CONJUGATE

Publication Number WO/2020/112642
Publication Date 04.06.2020
International Application No. PCT/US2019/063020
International Filing Date 25.11.2019
IPC
A61K 38/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
20Interleukins
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 38/202
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
19Cytokines; Lymphokines; Interferons
20Interleukins [IL]
202IL-3
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
Applicants
  • STEMLINE THERAPEUTICS, INC. [US]/[US]
Inventors
  • PORADOSU, Enrique
Agents
  • SCHOENHARD, Amy E.L.
  • MCNEILL, Rebecca M.
  • BAUR, Amelia F.
  • SCARR, Rebecca B.
  • HENNINGER, Mary R.
  • DOHERTY, Elizabeth A.
  • BREIER, Adam M.
  • HERZFELD, Deborah M.
  • PRYBYLOWSKI, Kate
  • LEE, Victoria
  • CHO, Hojung
  • CISAR, Elizabeth A.G.
  • MCELHONE, Katharine E.
Priority Data
62/773,53030.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMPROVED METHODS OF TREATING MYELOPROLIFERATIVE NEOPLASMS WITH A DIPHTHERIA TOXIN-HUMAN INTERLEUKIN-3 CONJUGATE
(FR) MÉTHODES AMÉLIORÉES DE TRAITEMENT DE NÉOPLASMES MYÉLOPROLIFÉRATIFS AVEC UN CONJUGUÉ INTERLEUKINE-3 HUMAINE-TOXINE DIPHTÉRIQUE
Abstract
(EN)
The present invention provides methods for treating or inhibiting a myeloproliferative neoplasm (MPN) in a subject in need thereof, comprising administering to the subject a diphtheria toxin-human interleukin-3 conjugate (DT-IL3), wherein the subject has monocytosis.
(FR)
La présente invention concerne des méthodes de traitement ou d'inhibition d'un néoplasme myéloprolifératif (MPN) chez un sujet en ayant besoin, comprenant l'administration au sujet d'un conjugué interleukine-3 humaine-toxine diphtérique (DT-IL3), le sujet présentant une monocytose.
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