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1. WO2020112621 - METHODS AND SYSTEMS FOR IN VITRO CARDIAC DISEASE MODELING

Publication Number WO/2020/112621
Publication Date 04.06.2020
International Application No. PCT/US2019/062976
International Filing Date 25.11.2019
IPC
A61K 35/12 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
A61K 35/34 2015.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
34Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
CPC
A61K 35/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
A61K 35/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
34Muscles; Smooth muscle cells; Heart; Cardiac stem cells; Myoblasts; Myocytes; Cardiomyocytes
C12N 5/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor;
Applicants
  • THE MEDICAL COLLEGE OF WISCONSIN, INC. [US]/[US]
Inventors
  • BROECKEL, Ulrich
  • AGGARWAL, Praful
  • RADISCI, Milica
  • ZHAO, Yimu
Agents
  • KEATING, Thomas, J.
Priority Data
62/772,42828.11.2018US
62/885,94813.08.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHODS AND SYSTEMS FOR IN VITRO CARDIAC DISEASE MODELING
(FR) PROCÉDÉS ET SYSTÈMES DE MODÉLISATION DE MALADIE CARDIAQUE IN VITRO
Abstract
(EN)
A method for generating an in vitro cardiac tissue model. The method includes steps of: forming an elongated tissue by disposing a plurality of cardiomyocytes within a culture plate; culturing the tissue such that each end of the elongated tissue contacts one of a pair of attachment wires adhered to the culture plate; and electrically stimulating the elongated tissue in culture.
(FR)
La présente invention concerne un procédé de génération d’un modèle de tissu cardiaque in vitro. Le procédé comprend les étapes de : formation d’un tissu allongé en disposant une pluralité de cardiomyocytes dans une plaque de culture ; la culture du tissu de sorte que chaque extrémité du tissu allongé entre en contact avec l’un d’une paire de fils de fixation adhérant à la plaque de culture ; et la stimulation électrique du tissu allongé en culture.
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