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1. WO2020112595 - THERMORESPONSIVE OIL-IN-WATER NANOEMULSION

Publication Number WO/2020/112595
Publication Date 04.06.2020
International Application No. PCT/US2019/062929
International Filing Date 25.11.2019
IPC
A61K 8/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
04Dispersions; Emulsions
06Emulsions
A61K 8/37 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
33containing oxygen
37Esters of carboxylic acids
A61K 8/39 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
33containing oxygen
39Derivatives containing from 2 to 10 oxyalkylene groups
A61K 8/49 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
49containing heterocyclic compounds
A61K 8/86 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
72containing organic macromolecular compounds
84obtained by reactions other than those involving only carbon-to-carbon unsaturated bonds
86Polyethers
A61K 8/90 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
72containing organic macromolecular compounds
90Block copolymers
CPC
A61K 2800/21
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2800Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
20Chemical, physico-chemical or functional or structural properties of the composition as a whole
21Emulsions characterized by droplet sizes below 1 micron
A61K 2800/262
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2800Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
20Chemical, physico-chemical or functional or structural properties of the composition as a whole
26Optical properties
262Transparent; Translucent
A61K 2800/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
2800Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
20Chemical, physico-chemical or functional or structural properties of the composition as a whole
30Characterized by the absence of a particular group of ingredients
34Free of silicones
A61K 47/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
A61K 8/062
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
02characterised by special physical form
04Dispersions; Emulsions
06Emulsions
062Oil-in-water emulsions
A61K 8/37
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
33containing oxygen
37Esters of carboxylic acids
Applicants
  • L'OREAL [FR]/[FR]
  • MASSACHUSETTS INSTITUTE OF TECHNOLOGY [US]/[US]
Inventors
  • ZARKET, Brady
  • DOYLE, Patrick, S.
  • BADRUDDOZA, Abu, Zayed Md
  • HASHEMNEJAD, Seyedmeysam
  • AMIN, Samiul
  • CASSIN, Guillaurne
  • CASTANEDA, Carlos, Ricardo
Agents
  • BALLS, James, R.
Priority Data
62/773,60630.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) THERMORESPONSIVE OIL-IN-WATER NANOEMULSION
(FR) NANOÉMULSION HUILE DANS L'EAU THERMOSENSIBLE
Abstract
(EN)
The present disclosure relates to thermoresponsive oil-in-water nanoemulsions that include: (a) one or more amphiphilic triblock copolymers; (b) one or more oils in the form of nanoemulsion droplets having an average size of about 20 nm to about 500 nm; (c) about 5 to about 40 wt.% of one or more surfactants; (d) one or more nonionic co¬ surfactants; and (e) water, wherein the nonemulsion undergoes a sol-to-gel transition at about 20°C to about 50°C. One or more lipophilic active ingredients and/or one or more hydrophilic active ingredients may be incorporated into the nanoemulsions. The nanoemulsions are particularly useful for medical, pharmaceutical, and cosmetic applications.
(FR)
La présente invention concerne des nanoémulsions huile dans l'eau thermosensibles qui comprennent : (a) un ou plusieurs copolymères triblocs amphiphiles ; (b) une ou plusieurs huiles sous la forme de gouttelettes de nanoémulsion ayant une taille moyenne d'environ 20 nm à environ 500 nm ; (c) environ 5 à environ 40 % en poids d'un ou de plusieurs tensio-actifs ; (d) un ou plusieurs co-tensio-actifs non ioniques ; et (e) de l'eau, dans lesquelles la nanoémulsion est soumise à une transition sol-gel à une température d'environ 20 °C à environ 50 °C. Un ou plusieurs principes actifs lipophiles et/ou un ou plusieurs principes actifs hydrophiles peuvent être incorporés dans les nanoémulsions. Les nanoémulsions sont particulièrement utiles pour des applications médicales, pharmaceutiques et cosmétiques.
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