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1. WO2020112588 - ANTIBODY COMPRISING A GLUTAMINE-CONTAINING LIGHT CHAIN C-TERMINAL EXTENSION, CONJUGATES THEREOF, AND METHODS AND USES

Publication Number WO/2020/112588
Publication Date 04.06.2020
International Application No. PCT/US2019/062913
International Filing Date 25.11.2019
IPC
A61K 47/68 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
CPC
A61K 47/6811
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
6801Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
6803Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
6811the drug being a protein or peptide, e.g. transferrin or bleomycin
A61K 47/6851
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
6835the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
6851the antibody targeting a determinant of a tumour cell
Applicants
  • BRISTOL-MYERS SQUIBB COMPANY [US]/[US]
Inventors
  • STROP, Pavel
  • RAO-NAIK, Chetana
  • DENG, Xiaodi
  • SHEPPARD, Paul O.
  • HOLDER, Patrick G.
  • YAMAZOE, Sayumi
Agents
  • CHAO, Yuan
  • BARBIC, Andrej
  • BELLOMY, Gregory R.
  • CLAUSS, Isabelle M.
  • COULTER, Kathryn
  • DELAUNEY, Ashton J.
  • FARQUHARSON-TORRES, Serena
  • GOLIAN, Paul D.
  • GREENBLATT, Gary D.
  • GUO, Z. Angela
  • HADAD, Henry
  • HAN, Bo
  • HAI, Bing
  • JACOBSEN, Barry H.
  • KORSEN, Elliott
  • LAUB, Friedrich Bernhard
  • LIU, Hong
  • SUN, Jing G.
  • VANATTEN, Mary K.
  • VOM WEGE, Julia
  • WALSH, Brian J.
Priority Data
62/773,70830.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTIBODY COMPRISING A GLUTAMINE-CONTAINING LIGHT CHAIN C-TERMINAL EXTENSION, CONJUGATES THEREOF, AND METHODS AND USES
(FR) ANTICORPS COMPRENANT UNE EXTENSION C-TERMINALE DE CHAÎNE LÉGÈRE CONTENANT DE LA GLUTAMINE, CONJUGUÉS DE CELUI-CI, ET MÉTHODES ET UTILISATIONS
Abstract
(EN)
An antibody has a glutamine-containing extension at the C-terminus of a light chain thereof, making it suitable for conjugation via transglutaminase-mediated transamidation.
(FR)
Un anticorps a une extension contenant de la glutamine à l'extrémité C-terminale d'une chaîne légère de celui-ci, ce qui le rend approprié pour une conjugaison par transamidation médiée par la transglutaminase.
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