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1. WO2020112581 - NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2, 3-DIOXYGENASE (IDO) INHIBITORS

Publication Number WO/2020/112581
Publication Date 04.06.2020
International Application No. PCT/US2019/062902
International Filing Date 25.11.2019
IPC
A61K 31/416 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4151,2-Diazoles
416condensed with carbocyclic ring systems, e.g. indazole
C07D 231/56 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
231Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
54condensed with carbocyclic rings or ring systems
56Benzopyrazoles; Hydrogenated benzopyrazoles
CPC
A61K 31/416
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
4151,2-Diazoles
416condensed with carbocyclic ring systems, e.g. indazole
C07D 231/54
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
231Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
54condensed with carbocyclic rings or ring-systems
C07D 231/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
231Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
54condensed with carbocyclic rings or ring-systems
56Benzopyrazoles; Hydrogenated benzopyrazoles
C07D 401/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 401/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
14containing three or more hetero rings
C07D 403/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
Applicants
  • MERCK SHARP & DOHME CORP. [US]/[US]
  • CLAUSEN, Dane [US]/[US] (US)
  • CHEN, Ping [US]/[US] (US)
  • FRADERA, Xavier [ES]/[US] (US)
  • GUO, Liangqin [US]/[US] (US)
  • HAN, Yongxin [CA]/[US] (US)
  • HE, Shuwen [CN]/[US] (US)
  • HUANG, Xianhai [CN]/[US] (US)
  • KOZLOWSKI, Joseph [US]/[US] (US)
  • LI, Guoqing [US]/[US] (US)
  • MARTINOT, Theodore, A. [US]/[US] (US)
  • PASTERNAK, Alexander [US]/[US] (US)
  • VERRAS, Andreas [US]/[US] (US)
  • XIAO, Li [US]/[US] (US)
  • YU, Wensheng [CN]/[US] (US)
  • ZHANG, Rui [US]/[US] (US)
Inventors
  • CLAUSEN, Dane
  • CHEN, Ping
  • FRADERA, Xavier
  • GUO, Liangqin
  • HAN, Yongxin
  • HE, Shuwen
  • HUANG, Xianhai
  • KOZLOWSKI, Joseph
  • LI, Guoqing
  • MARTINOT, Theodore, A.
  • PASTERNAK, Alexander
  • VERRAS, Andreas
  • XIAO, Li
  • YU, Wensheng
  • ZHANG, Rui
  • YE, Feng
Common Representative
  • MERCK SHARP & DOHME CORP.
Priority Data
62/772,35728.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL SUBSTITUTED PIPERAZINE AMIDE COMPOUNDS AS INDOLEAMINE 2, 3-DIOXYGENASE (IDO) INHIBITORS
(FR) NOUVEAUX COMPOSÉS DE PIPERAZINE AMIDE SUBSTITUÉS UTILISÉS EN TANT QU'INHIBITEURS DE L'INDOLÉAMINE 2,3-DIOXYGÉNASE (IDO)
Abstract
(EN)
Disclosed herein are compounds of formula (I) which are inhibitors of an IDO enzyme: (I). Also disclosed herein are uses of the compounds in the potential treatment or prevention of an IDO-associated disease or disorder. Also disclosed herein are compositions comprising these compounds. Further disclosed herein are uses of the compositions in the potential treatment or prevention of an IDO-associated disease or disorder.
(FR)
L'invention concerne des composés de formule (I) qui sont des inhibiteurs d'une enzyme IDO : (I) L'invention concerne également des utilisations des composés dans le traitement potentiel ou la prévention potentielle d'une maladie ou d'un trouble associé à l'IDO. L'invention concerne également des compositions comprenant ces composés. L'invention concerne en outre des utilisations des compositions dans le traitement potentiel ou la prévention potentielle d'une maladie ou d'un trouble associé à l'IDO.
Latest bibliographic data on file with the International Bureau