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International application No. Applicant's or agent's file reference
PCT/US2018/062411 12341-00-WO
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
26 November 2018
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:

5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
none of the figures is to be published with the abstract.


     A61K 8/49 (2006.01)i; A61K 8/92 (2006.01)i; A61Q 19/10 (2006.01)i; A61Q 17/00 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC


Minimum documentation searched (classification system followed by classification symbols):
     A61K; A61Q
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, CHEM ABS Data, WPI Data


Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
US 2003235550 A1 (PAN ROBERT YA-LIN [US] ET AL) 25 December 2003 (2003-12-25)
page 8 - page 9; tables 1,2
WO 9927904 A1 (JOHNSON & SON INC S C [US]) 10 June 1999 (1999-06-10)
pages 15-18; examples 1,4,56,
US 2013230609 A1 (MODAK SHANTA [US] ET AL) 05 September 2013 (2013-09-05)
page 13
EP 3159012 A1 (LG BIONANO LLC [US]) 26 April 2017 (2017-04-26)
paragraphs [0157] - [0162]
Special categories of cited documents:
document defining the general state of the art which is not considered to be of particular relevance
document cited by the applicant in the international application
earlier application or patent but published on or after the international filing date
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
document referring to an oral disclosure, use, exhibition or other means
document published prior to the international filing date but later than the priority date claimed
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
document member of the same patent family


Patent document cited in search report Publication date
Patent family member(s) Publication date
US 2003235550 A1
25 December 2003
AR 040447 A1
US 2003235550 A1
US 2004001797 A1
06 April 2005
25 December 2003
01 January 2004
WO 9927904 A1
10 June 1999
AR 017795 A1
AU 738286 B2
BR 9813382 A
CA 2312886 A1
CN 1280488 A
DE 69807926 T2
EP 1035832 A1
ES 2183430 T3
JP 4286451 B2
JP 2001524508 A
KR 20010032756 A
MX 221079 B
US 6264963 B1
WO 9927904 A1
ZA 9810931 B
24 October 2001
13 September 2001
10 October 2000
10 June 1999
17 January 2001
22 May 2003
20 September 2000
16 March 2003
01 July 2009
04 December 2001
25 April 2001
22 June 2004
24 July 2001
10 June 1999
31 May 1999
US 2013230609 A1
05 September 2013
EP 3159012 A1
26 April 2017
AR 106403 A1
BR 102016024625 A2
CA 2945444 A1
CN 107028881 A
EP 3159012 A1
JP 6266051 B2
JP 2017081896 A
KR 20170048190 A
PH 12016000352 A1
SG 10201608533V A
TW 201714605 A
US 2017112764 A1
ZA 201606887 B
10 January 2018
27 March 2018
23 April 2017
11 August 2017
26 April 2017
24 January 2018
18 May 2017
08 May 2017
11 April 2018
30 May 2017
01 May 2017
27 April 2017
29 November 2017
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
04 June 2019
Date of mailing of the international search report:
13 June 2019
Authorized officer:
Bader, Karl Günther
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