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1. WO2020111960 - AN IMPLANTOLOGICAL COMPOSITION COMPRISING CYSTATIN AND ITS USE IN BONE IMPLANTOLOGY

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[ EN ]

Claims

1. Implantological composition comprising cystatin, a carrier, a neutralizing agent, water or buffer, characterized in that it comprises cystatin with specific activity of at least 10 inhibitor units per milligram of protein in the amount of 0.02% (by weight), a carrier substance in the amount of 15.0% to 20.0% (by weight) and a neutralizing agent in the amount of no more than necessary to obtain a suitable pH value, preferably selected from the group comprising: NaOH or TEA, and the composition comprising deionized water or PBS buffer making up to 100% (by weight) of the weight of the composition.

2. The composition of claim 1 , characterized in that the carrier substance is poloxamer 407.

3. The composition of claim 1 to 2, characterized in that the composition comprises a gelling agent in the amount of no more than 0.25% (by weight) of the weight of the composition.

4. The composition of claim 1 to 3, characterized in that an adhesive properties enhancing substance is carbomer 974P or carbomer 971 P.

5. The composition of claim 1 to 4, characterized in that the composition comprises additives.

6. The composition of claim 1 to 5, characterized in that the additives constitute from 0% to 25% (by weight) of the weight of the composition.

7. The composition of claim 1 to 6, characterized in that the additives are selected from the group comprising: parabens (nipagins), glycerol, polyoxyethylene glycol 200, propylene glycol.

8. The composition of claim 1 to 7, characterized in that cystatin is of animal or plant origin or it is human recombinant.

9. The composition of claim 1 to 8, characterized in that the suitable pH of the composition is 7.40 ± 0.05.

10. The composition of claim 1 to 9, characterized in that the composition is in a liquid form in temperature of 20°C.

11. The composition of claim 1 to 10, characterized in that the composition is in a gel form in temperature of 37°C.

12. Use of the implantological composition as defined in claim 1 to 11 for coating implants or for local administration to promote osseointegration.