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1. WO2020111960 - AN IMPLANTOLOGICAL COMPOSITION COMPRISING CYSTATIN AND ITS USE IN BONE IMPLANTOLOGY

Publication Number WO/2020/111960
Publication Date 04.06.2020
International Application No. PCT/PL2019/050069
International Filing Date 27.11.2019
IPC
A61L 27/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
28Materials for coating prostheses
A61L 27/54 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
54Biologically active materials, e.g. therapeutic substances
A61K 38/55 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
55Protease inhibitors
CPC
A61K 38/55
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
55Protease inhibitors
A61K 47/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61L 2300/252
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2300Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
20containing or releasing organic materials
252Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines
A61L 2300/404
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2300Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
40characterised by a specific therapeutic activity or mode of action
404Biocides, antimicrobial agents, antiseptic agents
A61L 2300/434
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2300Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
40characterised by a specific therapeutic activity or mode of action
432Inhibitors, antagonists
434of enzymes
A61L 2430/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2430Materials or treatment for tissue regeneration
02for reconstruction of bones; weight-bearing implants
Applicants
  • UNIWERSYTET MEDYCZNY IM. PIASTÓW ŚLĄSKICH WE WROCŁAWIU [PL]/[PL]
Inventors
  • BARANOWSKI, Przemysław
  • GOŁĄB, Krzysztof
  • GBUREK, Jakub
  • PLUTA, Janusz
  • KAROLEWICZ, Bożena
  • ANTOSZEWSKA-SMITH, Joanna
  • JUSZCZYŃSKA, Katarzyna Jadwiga
  • SEBZDA, Tadeusz Przemysław
Agents
  • WITEK, Andrzej
Priority Data
P.42790928.11.2018PL
Publication Language English (EN)
Filing Language Polish (PL)
Designated States
Title
(EN) AN IMPLANTOLOGICAL COMPOSITION COMPRISING CYSTATIN AND ITS USE IN BONE IMPLANTOLOGY
(FR) COMPOSITION IMPLANTABLE COMPRENANT DE LA CYSTATINE ET SON UTILISATION EN IMPLANTOLOGIE OSSEUSE
Abstract
(EN)
The first object of the invention is an implantological composition comprising cystatin, a carrier, a neutralizing agent, deionized water or buffer, characterized in that it comprises cystatin with specific activity of at least 10 inhibitor units per milligram of protein in the amount of 0.02% (by weight), a carrier substance in the amount of 15.0% to 20.0% (by weight) and a neutralizing agent in the amount of no more than necessary to obtain a suitable pH value, preferably selected from the group comprising: NaOH or TEA, and the composition comprising deionized water or PBS buffer making up to 100% (by weight) of the weight of the composition. The second object of the invention is a use of the implantological composition for coating implants or for local administration to promote osseointegration.
(FR)
Le premier objet de l'invention est une composition implantable comprenant de la cystatine, un support, un agent neutralisant, de l'eau désionisée ou un tampon, caractérisé par le fait qu'elle comprend de la cystatine ayant une activité spécifique d'au moins 10 unités inhibitrices par milligramme de protéine dans la quantité de 0,02 % (en poids), une substance support dans la quantité de 15,0 % à 20,0 % (en poids) et un agent neutralisant dans la quantité de pas plus que nécessaire pour obtenir une valeur de pH appropriée, de préférence choisie dans le groupe comprenant : NaOH ou TEA, et la composition comprenant de l'eau désionisée ou du tampon PBS constituant jusqu'à 100 % (en poids) du poids de la composition. Le second objet de l'invention est une utilisation de la composition implantable pour revêtir des implants ou pour une administration locale pour favoriser l'ostéointégration.
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