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1. WO2020111888 - SYNOVIAL FLUID SUPPLEMENT COMPOSITION COMPRISING HYALURONIC ACID

Publication Number WO/2020/111888
Publication Date 04.06.2020
International Application No. PCT/KR2019/016778
International Filing Date 29.11.2019
IPC
A61L 27/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
14Macromolecular materials
20Polysaccharides
A61L 27/54 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
50Materials characterised by their function or physical properties
54Biologically active materials, e.g. therapeutic substances
A61K 31/728 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
726Glycosaminoglycans, i.e. mucopolysaccharides
728Hyaluronic acid
A61K 47/26 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61M 5/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
5Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm rests
178Syringes
28Syringe ampoules or cartridges, i.e. ampoules or cartridges provided with a needle
CPC
A61K 31/728
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
726Glycosaminoglycans, i.e. mucopolysaccharides
728Hyaluronic acid
A61K 47/26
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61L 27/20
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
14Macromolecular materials
20Polysaccharides
A61L 27/54
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
50Materials characterised by their function or physical properties ; , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
54Biologically active materials, e.g. therapeutic substances
A61M 5/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
MDEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY
5Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
178Syringes
28Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
Applicants
  • 주식회사 엘지화학 LG CHEM, LTD. [KR]/[KR]
Inventors
  • 정현태 JUNG, Hyun Tae
  • 이현섭 LEE, Hyun Sup
  • 장인석 CHANG, In Seok
  • 김상은 KIM, Sang Eun
  • 소진언 SO, Jin Eon
  • 김태협 KIM, Tae Hyeob
Agents
  • 유미특허법인 YOU ME PATENT AND LAW FIRM
Priority Data
10-2018-015291930.11.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) SYNOVIAL FLUID SUPPLEMENT COMPOSITION COMPRISING HYALURONIC ACID
(FR) COMPOSITION DE SUPPLÉMENT DE LIQUIDE SYNOVIAL COMPRENANT DE L'ACIDE HYALURONIQUE
(KO) 히알루론산을 포함하는 활액보충재용 조성물
Abstract
(EN)
The present invention relates to a synovial fluid supplement composition comprising hyaluronic acid. The synovial fluid supplement composition suppresses a decrease in the molecular weight of hyaluronic acid and preserves viscoelasticity by satisfying unique conditions in frequency sweep test and rate sweep test, thereby increasing the stability of preparations, and significantly reduces pain that may occur in patients by satisfying the osmotic pressure and pH range similar to normal synovial fluid. Accordingly, the synovial fluid supplement composition is useful for replenishing the synovial fluid lost during arthroscopic surgery, expediting functional recovery due to reduced friction in joints, reducing the risk of surgical site infections in joint surgery, and alleviating pain in patients.
(FR)
La présente invention concerne une composition de supplément de liquide synovial comprenant de l'acide hyaluronique. La composition de supplément de liquide synovial supprime une diminution du poids moléculaire de l'acide hyaluronique et préserve la viscoélasticité en satisfaisant des conditions uniques dans un test de balayage de fréquence et un test de balayage de vitesse, ce qui augmente la stabilité des préparations, et réduit significativement la douleur qui peut survenir chez des patients en satisfaisant la pression osmotique et la plage de pH similaires à un liquide synovial normal. Par conséquent, la composition de supplément de liquide synovial est utile pour reconstituer le liquide synovial perdu pendant une chirurgie arthroscopique, accélérer la récupération fonctionnelle en raison d'un frottement réduit dans des articulations, réduire le risque d'infections de site chirurgical lors d'une chirurgie articulaire, et soulager la douleur chez les patients.
(KO)
본 발명은 히알루론산을 포함하는 관절활액보충재용 조성물에 관한 것으로, 진동수 변화 시험(Frequency Sweep Test) 및 전단 속도 변화 시험(Rate Sweep Test)에서 특유의 조건을 만족함으로써 히알루론산 분자량의 감소를 억제시키고 점탄성을 유지시켜 제제의 안정성을 높이고, 정상 관절활액과 유사한 삼투압과 pH 범위를 만족시켜 환자에게 발생할 수 있는 통증을 현저하게 경감시킬 수 있어 관절경 수술시에 소실되는 활액의 대체, 관절부의 마찰 경감으로 인한 신속한 기능성 회복, 관절 수술 부위의 감염 위험도 경감, 환자의 통증 완화용으로 유용하다.
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