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1. WO2020111887 - BRAIN-DERIVED VESICLE-SPECIFIC MARKER AND BRAIN DISEASE DIAGNOSTIC METHOD USING SAME

Publication Number WO/2020/111887
Publication Date 04.06.2020
International Application No. PCT/KR2019/016777
International Filing Date 29.11.2019
IPC
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
G01N 33/53 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
CPC
G01N 33/53
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Applicants
  • 차의과학대학교 산학협력단 CHA UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR]/[KR]
Inventors
  • 문지숙 MOON, Ji Sook
Agents
  • 리앤목 특허법인 Y.P.LEE, MOCK & PARTNERS
Priority Data
10-2018-015271430.11.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) BRAIN-DERIVED VESICLE-SPECIFIC MARKER AND BRAIN DISEASE DIAGNOSTIC METHOD USING SAME
(FR) MARQUEUR SPÉCIFIQUE DE VÉSICULE DÉRIVÉ DU CERVEAU ET MÉTHODE DE DIAGNOSTIC DE MALADIE CÉRÉBRALE UTILISANT CE DERNIER
(KO) 뇌 유래 소포체 특이적 마커 및 이를 이용한 뇌 질병 진단 방법
Abstract
(EN)
The present invention relates to a brain-derived vesicle-specific marker and a brain disease diagnostic method using same. According to one aspect, by using a marker which specifically expresses in brain-derived vesicles, brain-derived vesicles can be isolated in a highly efficient and highly specific manner without having to collect tissues, and vesicles which specifically express in each region of the brain can be isolated. A brain disease condition can be diagnosed by means of an expression profile of a marker specific to a brain region in brain-derived vesicles which have been isolated by means of the marker according to one aspect.
(FR)
La présente invention concerne un marqueur spécifique de vésicule dérivée du cerveau et une méthode de diagnostic de maladie du cerveau utilisant ce dernier. Selon un aspect, par l'utilisation d'un marqueur qui s'exprime spécifiquement dans des vésicules dérivées du cerveau, des vésicules dérivées du cerveau peuvent être isolées de manière hautement efficace et hautement spécifique sans avoir à collecter de tissus, et des vésicules qui s'expriment spécifiquement dans chaque région du cerveau peuvent être isolées. Un état pathologique du cerveau peut être diagnostiqué au moyen d'un profil d'expression d'un marqueur spécifique d'une région cérébrale dans des vésicules dérivées du cerveau ayant été isolées au moyen du marqueur selon un aspect.
(KO)
뇌 유래 소포체 특이적 마커 및 이를 이용한 뇌 질병 진단 방법에 관한 것이다. 일 양상에 따른 마커는 뇌 유래 소포체에서 특이적으로 발현하는 마커를 이용하여 조직을 채취하지 않고도 뇌 유래 소포체를 고효율 및 고특이적으로 분리할 수 있고, 각 뇌 영역에서 특이적으로 발현하는 소포체를 분리할 수 있다. 또한 일 양상에 따른 마커를 이용해 분리된 뇌 유래 소포체서 뇌 영역 특이적 마커의 발현 프로파일을 통해 뇌의 질병 상태를 진단할 수 있다.
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