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1. WO2020111753 - USE OF JULGI IN DIAGNOSING AND TREATING GUANINE-QUADRUPLEX-RELATED DISEASE

Publication Number WO/2020/111753
Publication Date 04.06.2020
International Application No. PCT/KR2019/016419
International Filing Date 27.11.2019
IPC
G01N 33/68 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
A61K 38/17 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 25/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 31/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
CPC
A61K 38/17
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17from animals; from humans
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 25/28
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
28for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
G01N 33/68
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
68involving proteins, peptides or amino acids
Applicants
  • 포항공과대학교 산학협력단 POSTECH RESEARCH AND BUSINESS DEVELOPMENT FOUNDATION [KR]/[KR]
  • 재단법인대구경북과학기술원 DAEGU GYEONGBUK INSTITUTE OF SCIENCE AND TECHNOLOGY [KR]/[KR]
Inventors
  • 황일두 HWANG, Il Doo
  • 조현우 CHO, Hyun Woo
  • 이성배 LEE, Sung Bae
  • 조현섭 CHO, Hyun Seob
Agents
  • 특허법인 아이시스 ISIS IP LAW LLC
Priority Data
10-2018-014934528.11.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) USE OF JULGI IN DIAGNOSING AND TREATING GUANINE-QUADRUPLEX-RELATED DISEASE
(FR) UTILISATION DE JULGI POUR LE DIAGNOSTIC ET LE TRAITEMENT DE MALADIE LIÉE À LA GUANINE-QUADRUPLEX
(KO) JULGI의 구아닌-사중합체 관련 질환의 진단 및 치료 용도
Abstract
(EN)
The present invention relates to a use of JULGI in diagnosing and treating guanine-quadruplex-related disease and, more particularly, to a guanine-quadruplex (G-quadruplex) detecting composition comprising JULGI protein or a protein having a homology of 80% or higher to the JULGI protein, a diagnostic composition comprising the detecting composition, a diagnostic kit comprising the diagnostic composition, a method for providing information for diagnosis of a neurodegenerative disease, cancer, or a viral infection disease which are in pathological correlation with G-quadruplex, and a pharmaceutical composition for prevention or treatment of a neurodegenerative disease, cancer, or a viral infection disease, the pharmaceutical composition comprising JULGI protein, a protein having a homology of 80% or more with the JULGI protein, or a mutant protein thereof. Thanks to the activity of binding to the G-quadruplex structure, JULGI according to the present invention is expected to be advantageously used in diagnosing or treating various diseases that are in pathological correlation with the abnormal formation and dissociation of the G-quadruplex structure.
(FR)
La présente invention concerne une utilisation de JULGI pour le diagnostic et le traitement d'une maladie liée à la guanine-quadruplex et, plus particulièrement, une composition de détection de guanine-quadruplex (G-quadruplex) comprenant la protéine JULGI ou une protéine ayant une homologie égale ou supérieure à 80 % à la protéine JULGI, une composition de diagnostic comprenant la composition de détection, un kit de diagnostic comprenant la composition de diagnostic, un procédé de fourniture d'informations de diagnostic d'une maladie neurodégénérative, d'un cancer ou d'une maladie à infection virale qui sont en corrélation pathologique avec la G-quadruplex, et une composition pharmaceutique de prévention ou de traitement d'une maladie neurodégénérative, d'un cancer, ou d'une maladie à infection virale, la composition pharmaceutique comprenant la protéine JULGI, une protéine ayant une homologie égale ou supérieure à 80 % à la protéine JULGI, ou une de ses protéines mutantes. Grâce à l'activité de liaison à la structure de G-quadruplex, on s'attend à ce que la protéine JULGI selon la présente invention soit avantageusement utilisée pour le diagnostic ou le traitement de diverses maladies qui sont en corrélation pathologique avec la formation et la dissociation anormales de la structure de G-quadruplex.
(KO)
본 발명은 JULGI의 구아닌-사중합체 관련 질환의 진단 및 치료 용도에 관한 것으로, 보다 구체적으로는 JULGI 단백질 또는 상기 단백질과 80% 이상의 상동성을 갖는 단백질을 포함하는, 구아닌-사중합체(G-quadruplex) 검출용 조성물, 상기 검출용 조성물을 포함하는 진단용 조성물 및 상기 진단용 조성물을 포함하는 진단 키트, 구아닌-사중합체와 병리적 상관관계를 가지는 퇴행성 신경질환, 암 또는 바이러스 감염 질환의 진단을 위한 정보제공방법, JULGI 단백질 또는 상기 단백질과 80% 이상의 상동성을 갖는 단백질, 또는 이의 돌연변이 단백질을 포함하는 퇴행성 신경질환, 암, 또는 바이러스 감염질환의 예방 또는 치료용 약학적 조성물에 관한 것이다. 본 발명에 따른 JULGI은 G-quadruplex 구조에 결합하는 활성에 기인하여 G-quadruplex 구조의 비정상적인 형성 및 해리와 병리학적인 상관관계를 가지는 다양한 질환의 진단 또는 치료에 유용하게 이용될 수 있을 것으로 기대된다.
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