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1. WO2020111614 - DOUBLE STRANDED OLIGONUCLEOTIDE CONSTRUCT COMPRISING ANDROGEN RECEPTOR SPECIFIC SEQUENCE, AND COMPOSITION FOR PREVENTING HAIR LOSS AND PROMOTING HAIR GROWTH COMPRISING SAME

Publication Number WO/2020/111614
Publication Date 04.06.2020
International Application No. PCT/KR2019/015723
International Filing Date 18.11.2019
IPC
A61K 47/60 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
59obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
60the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61K 47/58 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
58obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyacrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
A61K 47/54 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
A61K 47/69 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 31/713 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
713Double-stranded nucleic acids or oligonucleotides
A61P 17/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
14for baldness or alopecia
CPC
A61K 31/713
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
713Double-stranded nucleic acids or oligonucleotides
A61K 47/54
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
54the modifying agent being an organic compound
A61K 47/58
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
58obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
A61K 47/60
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
56the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
59obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
60the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
A61K 47/69
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
A61K 8/60
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
18characterised by the composition
30containing organic compounds
60Sugars; Derivatives thereof
Applicants
  • (주)바이오니아 BIONEER CORPORATION [KR]/[KR]
Inventors
  • 박한오 PARK, Han-Oh
  • 윤성일 YUN, Sung Il
  • 변상진 BYUN, Sang-Jin
  • 이명미 LEE, Myeong-Mi
  • 양승야 YANG, Seung Ya
Agents
  • 이처영 LEE, Cheo Young
  • 장제환 CHANG, Je Hwan
Priority Data
10-2018-014956228.11.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) DOUBLE STRANDED OLIGONUCLEOTIDE CONSTRUCT COMPRISING ANDROGEN RECEPTOR SPECIFIC SEQUENCE, AND COMPOSITION FOR PREVENTING HAIR LOSS AND PROMOTING HAIR GROWTH COMPRISING SAME
(FR) CONSTRUCTION D'OLIGONUCLÉOTIDE DOUBLE BRIN COMPORTANT UNE SÉQUENCE SPÉCIFIQUE DU RÉCEPTEUR AUX ANDROGÈNES, ET COMPOSITION LA COMPORTANT POUR PRÉVENIR LA PERTE DES CHEVEUX ET STIMULER LA POUSSE DES CHEVEUX
(KO) 안드로젠 수용체 특이적 서열을 포함하는 이중나선 올리고뉴클레오티드 구조체, 및 이를 포함하는 탈모 예방 및 발모용 조성물
Abstract
(EN)
The present invention relates to: a double stranded oligonucleotide construct having a structure of the form in which a hydrophilic material and a hydrophobic material are conjugated by a simple covalent bond or a linker-mediated covalent bond at both ends of a double stranded oligonucleotide in order to efficiently deliver an androgen receptor specific oligonucleotide into a cell; a nanoparticle which can be produced by self-assembling the double stranded oligonucleotide constructs in an aqueous solution by hydrophobic interaction; and a composition for preventing hair loss or for promoting hair growth comprising the double stranded oligonucleotide construct. The double stranded oligonucleotide construct comprising an androgen receptor specific oligonucleotide, and the composition for preventing hair loss or for promoting hair growth comprising the same as an active ingredient, according to the present invention, can inhibit the expression of an androgen receptor with high efficiency without side effects, and thus can have an excellent effect on the prevention of hair loss, especially androgenic hair loss, alopecia areata, and telogen alopecia and the promotion of hair growth.
(FR)
La présente invention concerne : une construction d'oligonucléotide double brin ayant une structure d'une forme dans laquelle un matériau hydrophile et un matériau hydrophobe sont conjugués par une liaison covalente simple ou une liaison covalente à médiation par un lieur aux deux extrémités d'un oligonucléotide double brin afin d'administrer efficacement un oligonucléotide spécifique du récepteur aux androgènes dans une cellule; une nanoparticule qui peut être produite par auto-assemblage des constructions d'oligonucléotide double brin dans une solution aqueuse par interaction hydrophobe; une composition pour prévenir la perte de cheveux ou pour stimuler la pousse des cheveux comportant la construction d'oligonucléotide double brin. La construction d'oligonucléotide double brin comprend un oligonucléotide spécifique du récepteur aux androgènes, et la composition pour prévenir la perte de cheveux ou pour stimuler la pousse des cheveux comportant celle-ci en tant que principe actif, selon la présente invention, permet d'inhiber l'expression du récepteur aux androgènes avec une efficacité élevée sans effets indésirables, et peut ainsi produire un excellent effet sur la prévention de la perte de cheveux, en particulier de l'alopécie androgénétique, de l'alopécie areata et de l'alopécie diffuse, et sur la stimulation de la pousse des cheveux.
(KO)
본 발명은 안드로젠 수용체 특이적 올리고뉴클레오티드를 세포 내로 효율적으로 전달하기 위하여 이중나선 올리고뉴클레오티드의 양 말단에 친수성 물질 및 소수성 물질이 단순 공유결합 또는 링커-매개(linker-mediated) 공유결합으로 접합된 형태의 구조를 가지는 이중나선 올리고뉴클레오티드 구조체, 수용액에서 상기 이중나선 올리고뉴클레오티드 구조체들이 소수성 상호작용에 의해 자가조립되어 생성될 수 있는 나노입자 및 상기 이중나선 올리고뉴클레오티드 구조체를 포함하는 탈모 예방 또는 발모용 조성물에 관한 것으로, 본 발명에 따른 안드로젠 수용체 특이적 올리고뉴클레오티드를 포함하는 이중나선 올리고뉴클레오티드 구조체 및 이를 유효성분으로 포함하는 탈모 예방 또는 발모용 조성물은 부작용 없이 높은 효율로 안드로젠 수용체의 발현을 억제할 수 있어, 탈모, 특히 안드로젠성 탈모, 원형 탈모, 휴지기 탈모의 예방 및 발모 유도에 탁월한 효과를 거둘 수 있다.
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