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1. WO2020111541 - COMPOSITION FOR PREVENTING OR TREATING PAIN, CONTAINING ACONINE AS ACTIVE INGREDIENT

Publication Number WO/2020/111541
Publication Date 04.06.2020
International Application No. PCT/KR2019/014663
International Filing Date 01.11.2019
IPC
A61K 31/40 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61P 29/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
A23L 33/10 2016.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
CPC
A23L 33/10
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
A61K 31/40
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
A61K 9/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
Applicants
  • 한국기초과학지원연구원 KOREA BASIC SCIENCE INSTITUTE [KR]/[KR]
Inventors
  • 장익순 JANG, Ik Soon
  • 최종순 CHOI, Jong Soon
  • 이제호 LEE, Je Ho
Agents
  • 특허법인 아이시스 ISIS IP LAW LLC
Priority Data
10-2018-015248830.11.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION FOR PREVENTING OR TREATING PAIN, CONTAINING ACONINE AS ACTIVE INGREDIENT
(FR) COMPOSITION POUR LA PRÉVENTION OU LE TRAITEMENT DE LA DOULEUR, CONTENANT DE L'ACONINE EN TANT QUE PRINCIPE ACTIF
(KO) 아코닌을 유효성분으로 포함하는 통증 예방 또는 치료용 조성물
Abstract
(EN)
The present invention relates to a composition for preventing, treating or alleviating pain, containing, as an active ingredient, aconine or a pharmaceutically acceptable salt thereof. The inventors of the present invention have ascertained that: a toxic component of natural product-derived aconine, obtained by the hydrolysis of aconitine, which is a toxic component of Aconiti Kusnezoffii Tuber, through heating after passing a water immersion fabric, is removed so that safety is ensured; rapid absorption and pain inhibition effects are exhibited even during oral administration, which has lower activity than injections; and effects similar to those of commercial products are exhibited, and thus it is expected that safety against side effects is ensured so that the present invention is effectively usable in preventing, treating or alleviating pain.
(FR)
La présente invention concerne une composition pour la prévention, le traitement ou le soulagement de la douleur, contenant, en tant que principe actif, de l'aconine ou un sel de qualité pharmaceutique de celle-ci. Les inventeurs de la présente invention ont déterminé que : un composant toxique de l'aconine dérivée d'un produit naturel, obtenue par l'hydrolyse de l'aconitine, qui est un composant toxique du tubercule d'Aconiti Kusnezoffii, par chauffage après passage à travers un tissu immergé dans l'eau, est éliminé pour assurer la sécurité; des effets d'absorption rapide et d'inhibition de la douleur sont démontrés même dans le cas d'une administration orale, caractérisée par une activité inférieure à celle observée en cas d'injection; et des effets similaires à ceux des produits du commerce sont démontrés et, par conséquent, on s'attend à ce qu'il n'y ait pas d'effets secondaires de façon à ce que la présente invention puisse être efficacement utilisée dans la prévention, le traitement ou le soulagement de la douleur.
(KO)
본 발명은 아코닌 (Aconine) 또는 이의 약학적으로 허용 가능한 염을 유효성분으로 포함하는, 통증 예방, 치료 또는 개선용 조성물에 관한 것으로서, 본 발명자들은 초오 (草烏)의 독성 성분인 아코니틴 (Aconitine)을 수침포 (水浸泡)를 거쳐 가열하는 가수분해를 통해 수득한 천연물 유래의 아코닌 (Aconine)이 독성 성분이 제거되어 안전성이 확보되었을 뿐만 아니라, 주사제와 비교하여 활성이 낮은 경구 투여 시에도 빠른 흡수 및 통증 저해 효과를 나타내는 것을 확인하였으며, 시판제품과 유사한 효과를 나타내는 것을 확인하였는바, 부작용에 대한 안전성이 확보되어 통증 예방, 치료 또는 개선 용도로 유용하게 이용될 수 있을 것으로 기대된다.
Also published as
Latest bibliographic data on file with the International Bureau