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1. WO2020111519 - PHARMACEUTICAL COMPOSITION COMPRISING, AS ACTIVE INGREDIENT, USP25 PROTEIN OR POLYNUCLEOTIDE FOR ENCRYPTING SAME

Publication Number WO/2020/111519
Publication Date 04.06.2020
International Application No. PCT/KR2019/014061
International Filing Date 24.10.2019
IPC
A61K 38/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
A61K 31/7088 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 19/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 19/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
CPC
A61K 31/7088
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
7088Compounds having three or more nucleosides or nucleotides
A61K 38/48
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
46Hydrolases (3)
48acting on peptide bonds (3.4)
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 19/02
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
02for joint disorders, e.g. arthritis, arthrosis
A61P 19/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19Drugs for skeletal disorders
08for bone diseases, e.g. rachitism, Paget's disease
Applicants
  • 연세대학교 산학협력단 INDUSTRY-ACADEMIC COOPERATION FOUNDATION, YONSEI UNIVERSITY [KR]/[KR]
Inventors
  • 이진우 LEE, Jin Woo
  • 박광환 PARK, Kwang Hwan
  • 정민 JUNG, Min
  • 이경미 LEE, Kyoung Mi
  • 백다운 BAEK, Da Woon
Agents
  • 이재영 LEE, Jae Young
Priority Data
10-2018-015218730.11.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) PHARMACEUTICAL COMPOSITION COMPRISING, AS ACTIVE INGREDIENT, USP25 PROTEIN OR POLYNUCLEOTIDE FOR ENCRYPTING SAME
(FR) COMPOSITION PHARMACEUTIQUE COMPRENANT COMME PRINCIPE ACTIF LA PROTÉINE USP25 OU UN POLYNUCLÉOTIDE CODANT CETTE DERNIÈRE
(KO) USP25 단백질 또는 이를 암호화하는 폴리뉴클레오티드를 유효성분으로 포함하는 약학 조성물
Abstract
(EN)
The present invention relates to a pharmaceutical composition for regenerating a tissue and, particularly, to a pharmaceutical composition for regenerating a tissue, comprising, as an active ingredient, ubiquitin carboxyl-terminal hydrolase 25 (USP25) protein or a polynucleotide for encrypting same. If the composition is used, compared to another deubiquitinating enzyme, a bone marrow-derived mesenchymal stem cell can be very effectively induced to be differentiated into a bone tissue cell, particularly a cartilage cell. By inducing such differentiation into a cartilage cell, the present invention can be very usefully applied for prevention or treatment of various diseases which can occur due to cartilage tissue damage.
(FR)
La présente invention concerne une composition pharmaceutique pour régénérer un tissu et, en particulier, une composition pharmaceutique pour régénérer un tissu comprenant comme principe actif la protéine à hydrolase de c-terminal d'ubiquitine (USP25) ou un polynucléotide codant cette dernière. Si la composition est utilisée, plutôt qu'une autre enzyme de désubiquitination, il est possible de très efficacement induire des cellules souches mésenchymateuses dérivées de la moelle osseuse à se différencier en cellules de tissu osseux, en particulier en cellules de cartilage. Du fait qu'elle induit une telle différenciation en cellules cartilagineuses, la présente invention peut être appliquée de manière très utile pour la prévention ou le traitement de diverses maladies qui peuvent découler d'une lésion du tissu cartilagineux.
(KO)
본 발명은 조직 재생용 약학 조성물에 관한 것으로, 구체적으로 USP25(Ubiquitin carboxyl-terminal hydrolase 25) 단백질 또는 이를 암호화하는 폴리뉴클레오티드를 유효성분으로 포함하는 조직 재생용 약학 조성물에 관한 것으로, 상기 조성물을 사용하는 경우, 다른 탈 유비퀴틴화 효소에 비하여 골수 유래 중간엽 줄기 세포가 골 조직 세포, 특히 연골 세포로 분화될 수 있도록 매우 효과적으로 유도할 수 있다. 또한, 이렇게 연골 세포로 분화될 수 있도록 유도함으로써 연골 조직이 손상되어 발생될 수 있는 다양한 질환의 예방 또는 치료에 매우 유용하게 적용될 수 있다.
Also published as
Latest bibliographic data on file with the International Bureau