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1. WO2020111501 - COMPOSITION FOR PREVENTING OR TREATING PARKINSON'S DISEASE, CONTAINING AEG-1 S298D AS ACTIVE INGREDIENT

Publication Number WO/2020/111501
Publication Date 04.06.2020
International Application No. PCT/KR2019/013284
International Filing Date 10.10.2019
IPC
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C12N 15/86 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
A23L 33/18 2016.01
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
17Amino acids, peptides or proteins
18Peptides; Protein hydrolysates
A61P 25/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
CPC
A23L 33/18
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
33Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
10using additives
17Amino acids, peptides or proteins
18Peptides; Protein hydrolysates
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 25/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
14for treating abnormal movements, e.g. chorea, dyskinesia
16Anti-Parkinson drugs
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
C12N 15/86
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79Vectors or expression systems specially adapted for eukaryotic hosts
85for animal cells
86Viral vectors
Applicants
  • 경북대학교 산학협력단 KYUNGPOOK NATIONAL UNIVERSITY INDUSTRY-ACADEMIC COOPERATION FOUNDATION [KR]/[KR]
Inventors
  • 김상룡 KIM, Sang Ryong
  • 신민상 SHIN, Minsang
  • 임은주 LEEM, Eunju
Agents
  • 특허법인 태백 TAEBAEK INTELLECTUAL PROPERTY LAW FIRM
Priority Data
10-2018-014963928.11.2018KR
Publication Language Korean (KO)
Filing Language Korean (KO)
Designated States
Title
(EN) COMPOSITION FOR PREVENTING OR TREATING PARKINSON'S DISEASE, CONTAINING AEG-1 S298D AS ACTIVE INGREDIENT
(FR) COMPOSITION PERMETTANT DE PRÉVENIR OU DE TRAITER LA MALADIE DE PARKINSON, CONTENANT AEG-1 S298D EN TANT QUE PRINCIPE ACTIF
(KO) AEG-1 S298D을 유효성분으로 포함하는 파킨슨 질환 예방 또는 치료용 조성물
Abstract
(EN)
The present invention relates to a composition for preventing or treating Parkinson's disease, containing AEG-1 (S298D) as an active ingredient. In the present invention, it is ascertained that, when AEG-1(S298D), which is a constitutively active form, is induced by introducing a point mutation into AEG-1 and AAV-AEG-1(S298D) is produced and applied to an animal model of Parkinson's disease, a brain tissue protection effect is exhibited by preserving dopamine neurons and dopamine nerve fibers, and thus AEG-1 can be effectively used in a composition for preventing or treating Parkinson's disease, a health food composition for preventing or alleviating Parkinson's disease, and the like.
(FR)
La présente invention concerne une composition permettant de prévenir ou de traiter la maladie de Parkinson, contenant AEG-1 (S298D) en tant que principe actif. Dans la présente invention, l'AEG-1(S298D), qui est une forme à activité constitutive est induit par introduction d'une mutation ponctuelle dans AEG-1 et l'AAV-AEG-1(S298D) est produit et appliqué à un modèle animal de maladie de Parkinson, ce qui permet d'obtenir un effet de protection de tissu cérébral par préservation des neurones de dopamine et des fibres nerveuses de dopamine, l'AEG-1 peut ainsi être utilisé de manière efficace dans une composition pour prévenir ou traiter la maladie de Parkinson, une composition d'aliment de santé pour prévenir ou soulager la maladie de Parkinson, et similaires.
(KO)
본 발명은 AEG-1(S298D)을 유효성분으로 포함하는 파킨슨 질환 예방 또는 치료용 조성물에 관한 것으로, 본 발명에서는 AEG-1에 점 돌연변이(point mutation)를 도입하여 구성적 활성(constitutively active) 형태인 AEG-1(S298D)을 유도하고, AAV-AEG-1(S298D)을 제조하여 파킨슨 질환 동물모델에 적용시킨 결과, 도파민 신경세포 및 도파민 신경섬유를 보존함으로써 뇌 조직 보호 효과를 나타내는 것을 확인한 바, AEG-1은 파킨슨 질환 예방 또는 치료용 조성물, 파킨슨 질환 예방 또는 개선용 건강식품 조성물 등으로 유용하게 활용될 수 있다.
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Latest bibliographic data on file with the International Bureau