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1. WO2020111272 - METHOD FOR DETECTING BACTERIUM RESPONSIBLE FOR ACUTE SINUSITIS CAUSED BY BACTERIAL INFECTION

Publication Number WO/2020/111272
Publication Date 04.06.2020
International Application No. PCT/JP2019/046906
International Filing Date 29.11.2019
IPC
C07K 14/285 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
285from Pasteurellaceae (F), e.g. Haemophilus influenza
C07K 14/315 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
315from Streptococcus (G), e.g. Enterococci
C07K 16/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
12against material from bacteria
G01N 33/543 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
G01N 33/569 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
CPC
C07K 14/285
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
285from Pasteurellaceae (F), e.g. Haemophilus influenza
C07K 14/315
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
315from Streptococcus (G), e.g. Enterococci
C07K 16/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
12against material from bacteria
G01N 33/543
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
G01N 33/569
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
Applicants
  • 旭化成株式会社 ASAHI KASEI KABUSHIKI KAISHA [JP]/[JP]
Inventors
  • 宮田 拓治 MIYATA, Takuji
  • 綾部 雅朗 AYABE, Masaaki
  • 岡村 哲和 OKAMURA, Norikazu
Agents
  • 青木 篤 AOKI, Atsushi
  • 三橋 真二 MITSUHASHI, Shinji
  • 中村 和広 NAKAMURA, Kazuhiro
  • 齋藤 都子 SAITO, Miyako
  • 三間 俊介 MIMA, Shunsuke
Priority Data
2018-22579330.11.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD FOR DETECTING BACTERIUM RESPONSIBLE FOR ACUTE SINUSITIS CAUSED BY BACTERIAL INFECTION
(FR) PROCÉDÉ DE DÉTECTION D'UNE BACTÉRIE RESPONSABLE DE LA SINUSITE AIGUË PROVOQUÉE PAR UNE INFECTION BACTÉRIENNE
(JA) 細菌感染による急性副鼻腔炎の起炎菌の検出方法
Abstract
(EN)
Provided is a detection means for identifying a bacterium responsible for acute sinusitis. According to the present invention, a method for detecting Haemophilus influenzae or Streptococcus pneumoniae responsible for acute sinusitis caused by bacterial infection, comprises: a step for measuring the per-cotton swab mass of ribosomal protein L7/L12 of the responsible bacterium in a nasal swab sample that is collected from a subject and attached to a cotton swab, using an antibody that specifically binds to ribosomal protein L7/L12 of the responsible bacterium, and that can be used to distinguish the responsible bacterium from other bacteria in terms at the genus or species level; and determining a determination criteria value (cut-off value) for determining whether a responsible bacterium has been detected or not on the basis of the measured value obtained.
(FR)
L'invention concerne un moyen de détection permettant d'identifier une bactérie responsable de la sinusite aiguë. La présente invention concerne un procédé de détection de Haemophilus influenzae ou de Streptococcus pneumoniae responsable de la sinusite aiguë provoquée par une infection bactérienne qui comprend : une étape consistant à mesurer la masse d'écouvillon par coton de la protéine ribosomale L7/L12 de bactérie responsable dans un échantillon d'écouvillon nasal collecté à partir d'un sujet et fixé à un coton-tige, à l'aide d'un anticorps qui se lie de manière spécifique à la protéine ribosomale L7/L12 de la bactérie responsable, et qui peut être utilisé pour distinguer la bactérie responsable d'autres bactéries en termes au niveau du genre ou de l'espèce ; et à déterminer une valeur de critère de détermination (valeur de coupure) pour déterminer si une bactérie responsable a été détectée ou non sur la base de la valeur mesurée obtenue.
(JA)
急性副鼻腔炎において、起炎菌を特定するための検出手段の提供。 細菌感染による急性副鼻腔炎の起炎菌であるインフルエンザ菌又は肺炎球菌の検出方法であって、被検体より採取した綿棒に付着した鼻腔ぬぐい液サンプル中の、該起炎菌のリボゾームL7/L12蛋白質の該綿棒当たりの換算質量を、該起炎菌のリボゾームL7/L12蛋白質に特異的に結合し、かつ、該起炎菌を他の細菌と種又は属で識別することができる抗体を用いて、測定し、得られた測定値に基づき起炎菌検出の有無を判断するための判断基準値(カットオフ値)を決定する工程を含む、上記検出方法。
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