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1. WO2020111248 - VACCINE PREPARATION

Publication Number WO/2020/111248
Publication Date 04.06.2020
International Application No. PCT/JP2019/046846
International Filing Date 29.11.2019
IPC
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 39/002 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
002Protozoa antigens
A61K 39/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 39/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
35Allergens
36from pollen
A61P 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
A61K 39/002
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
002Protozoa antigens
A61K 39/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
12Viral antigens
A61K 39/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
35Allergens
36from pollen
A61K 47/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
A61K 47/14
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
Applicants
  • 小林製薬株式会社 KOBAYASHI PHARMACEUTICAL CO., LTD. [JP]/[JP]
  • 国立大学法人九州大学 KYUSHU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION [JP]/[JP]
Inventors
  • 中田 孝広 NAKATA, Takahiro
  • 後藤 雅宏 GOTO, Masahiro
  • 小坂 秀斗 KOZAKA, Shuto
Agents
  • 田中 順也 TANAKA, Junya
  • 水谷 馨也 MIZUTANI, Keiya
  • 迫田 恭子 SAKODA, Kyoko
Priority Data
2018-22405929.11.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) VACCINE PREPARATION
(FR) PRÉPARATION DE VACCIN
(JA) ワクチン製剤
Abstract
(EN)
The purpose of the present invention is to provide a vaccine preparation that can induce excellent immunity through transdermal administration. This vaccine preparation includes: an aqueous phase having an antigen dissolve therein; glycerin fatty acid ester and/or poly-glycerin fatty acid ester; and an oil phase, wherein the aqueous phase is dispersed in the oil phase. The vaccine preparation can, when being administered transdermally, induce excellent immunity in a manner better than administration through injection.
(FR)
Le but de la présente invention est de fournir une préparation de vaccin qui peut induire une excellente immunité par administration transdermique. Cette préparation de vaccin comprend : une phase aqueuse dans laquelle un antigène se dissout ; un ester d'acide gras de glycérine et/ou un ester d'acide gras de poly-glycérine ; et une phase huileuse, dans laquelle la phase aqueuse est dispersée dans la phase huileuse. La préparation de vaccin peut, lorsqu'elle est administrée par voie transdermique, induire une excellente immunité d'une meilleure manière qu'une administration par injection.
(JA)
本発明の目的は、経皮投与によって優れた免疫誘導が可能なワクチン製剤を提供することである。 抗原が溶解した水相、グリセリン脂肪酸エステル及び/又はポリグリセリン脂肪酸エステル、並びに油相を含み、当該水相が当該油相に分散しているワクチン製剤は、経皮投与すると、注射投与を凌ぐ、優れた免疫誘導が可能になる。
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