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1. WO2020111167 - THERAPEUTIC AGENT FOR BREAST CANER COMPRISING BIG3-PHB2 INTERACTION-INHIBITING PEPTIDE DERIVED FROM PHB2

Publication Number WO/2020/111167
Publication Date 04.06.2020
International Application No. PCT/JP2019/046505
International Filing Date 28.11.2019
IPC
C12N 15/12 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
12Genes encoding animal proteins
A61K 38/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
10Peptides having 12 to 20 amino acids
A61K 38/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides
A61K 48/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/-A61P41/108
CPC
A61K 38/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
10Peptides having 12 to 20 amino acids
A61K 38/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
12Cyclic peptides ; , e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
A61K 48/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07K 14/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
Applicants
  • 国立大学法人徳島大学 TOKUSHIMA UNIVERSITY [JP]/[JP]
  • オンコセラピー・サイエンス株式会社 ONCOTHERAPY SCIENCE, INC. [JP]/[JP]
Inventors
  • 片桐 豊雅 KATAGIRI, Toyomasa
  • 吉丸 哲郎 YOSHIMARU, Tetsuro
  • 大高 章 OTAKA, Akira
  • 宮本 貴史 MIYAMOTO, Takashi
  • 岡本 康秀 OKAMOTO, Yasuhide
Agents
  • 春名 雅夫 HARUNA, Masao
  • 清水 初志 SHIMIZU, Hatsushi
  • 山口 裕孝 YAMAGUCHI, Hirotaka
  • 刑部 俊 OSAKABE, Suguru
  • 井上 隆一 INOUE, Ryuichi
  • 佐藤 利光 SATO, Toshimitsu
  • 新見 浩一 SHIMMI, Hirokazu
  • 小林 智彦 KOBAYASHI, Tomohiko
  • 小寺 秀紀 KODERA, Hideki
  • 大関 雅人 OHZEKI, Masato
  • 五十嵐 義弘 IGARASHI, Yoshihiro
  • 川本 和弥 KAWAMOTO, Kazuya
Priority Data
2018-22566030.11.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) THERAPEUTIC AGENT FOR BREAST CANER COMPRISING BIG3-PHB2 INTERACTION-INHIBITING PEPTIDE DERIVED FROM PHB2
(FR) AGENT THÉRAPEUTIQUE POUR LE TRAITEMENT DU CANCER DU SEIN COMPRENANT UN PEPTIDE INHIBITEUR D'INTERACTION BIG3-PHB2 DÉRIVÉ DE PHB2
(JA) BIG3-PHB2相互作用阻害PHB2由来ペプチドを含む乳がん治療薬
Abstract
(EN)
Provided are: a peptide which contains the BIG3 polypeptide-binding site in PHB2 polypeptide and inhibits the binding of PHB2 polypeptide to BIG3 polypeptide; and a pharmaceutical composition comprising this peptide. The peptide according to the present invention is capable of binding to not PHB2, which is expressed in human systemic organs, but BIG3, which is a protein highly expressed specifically in estrogen receptor-positive cancers, and has an excellent growth inhibitory effect on BIG3-positive cancer cells. Therefore, the peptide according to the present invention is useful as a therapeutic agent for breast cancer which can avoid the occurrence of side effects.
(FR)
L'invention porte sur un peptide comportant le site de liaison de polypeptide BIG3 dans le polypeptide PHB2, et inhibant la liaison du polypeptide PHB2 au polypeptide BIG3; et une composition pharmaceutique comprenant ce peptide. Le peptide selon la présente invention est capable de se lier non pas à PHB2, qui est exprimé dans des organes systémiques humains, mais à BIG3, qui est une protéine hautement exprimée particulièrement dans les cancers du sein positifs pour les récepteurs des œstrogènes, et présente un excellent effet inhibiteur sur la croissance des cellules cancéreuses positives à BIG3. Par conséquent, le peptide selon la présente invention est utile en tant qu'agent thérapeutique pour le traitement du cancer du sein qui peut éviter l'apparition d'effets secondaires.
(JA)
PHB2ポリペプチドにおけるBIG3ポリペプチドとの結合部位を含み、PHB2ポリペプチドとBIG3ポリペプチドとの結合を阻害するペプチド、及び該ペプチドを含む医薬組成物を提供する。本発明のペプチドは、ヒトの全身の臓器にて発現が認められるPHB2ではなく、特にエストロゲン受容体陽性のがんに特異的に高発現するタンパク質であるBIG3への結合能を有し、BIG3陽性のがん細胞に対して優れた増殖抑制作用を有する。そのため、本発明のペプチドは、副作用の発現を回避することができる乳がん治療薬として有用である。
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