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1. WO2020110831 - METHOD FOR PRODUCING THIOLACTONE DERIVATIVE

Publication Number WO/2020/110831
Publication Date 04.06.2020
International Application No. PCT/JP2019/045285
International Filing Date 19.11.2019
IPC
A61K 31/4188 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
41641,3-Diazoles
4188condensed with heterocyclic ring systems, e.g. biotin, sorbinil
A61P 3/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
C07D 495/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61K 31/4188
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
41641,3-Diazoles
4188condensed with other heterocyclic ring systems, e.g. biotin, sorbinil
A61P 3/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
08for glucose homeostasis
10for hyperglycaemia, e.g. antidiabetics
C07D 495/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • 株式会社トクヤマ TOKUYAMA CORPORATION [JP]/[JP]
Inventors
  • 関 雅彦 SEKI Masahiko
Agents
  • 加藤 竜太 KATO Ryuta
  • 岸武 弘樹 KISHITAKE Hiroki
  • 中馬 典嗣 CHUMA Noritsugu
Priority Data
2018-22243228.11.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD FOR PRODUCING THIOLACTONE DERIVATIVE
(FR) PROCÉDÉ DE PRODUCTION DE DÉRIVÉ DE THIOLACTONE
(JA) チオラクトン誘導体の製造方法
Abstract
(EN)
The present invention provides a method for producing a thiolactone derivative, which comprises a process wherein a crystal of a thiolactone derivative is obtained after bringing activated carbon and a solution containing a crude form of a thiolactone derivative represented by formula (1) into contact with each other. In the formula, each of R1 and R2 independently represents a hydrogen atom or a substituted or unsubstituted benzyl group.
(FR)
La présente invention concerne un procédé de production d'un dérivé de thiolactone, qui comprend un procédé dans lequel un cristal d'un dérivé de thiolactone est obtenu après mise en contact de charbon actif et d'une solution contenant une forme brute d'un dérivé de thiolactone représenté par la formule (1). Dans la formule, chaque radical R1 et R2 représente indépendamment un atome d'hydrogène ou un groupe benzyle substitué ou non substitué.
(JA)
下記式(1)で表されるチオラクトン誘導体の粗体を含む溶液と活性炭とを接触させた後、チオラクトン誘導体の結晶を得ることを含むチオラクトン誘導体の製造方法を提供する。式中、R及びRはそれぞれ独立に、水素原子、又は置換若しくは非置換のベンジル基を示す。
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