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1. WO2020110481 - COMPLEX AND DETECTION DEVICE

Publication Number WO/2020/110481
Publication Date 04.06.2020
International Application No. PCT/JP2019/040065
International Filing Date 10.10.2019
IPC
G01N 33/543 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
B82Y 15/00 2011.01
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE  OR TREATMENT OF NANOSTRUCTURES
15Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
C01B 33/02 2006.01
CCHEMISTRY; METALLURGY
01INORGANIC CHEMISTRY
BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF
33Silicon; Compounds thereof
02Silicon
C09K 11/59 2006.01
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
KMATERIALS FOR APPLICATIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
11Luminescent, e.g. electroluminescent, chemiluminescent, materials
08containing inorganic luminescent materials
59containing silicon
G01N 21/41 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
41Refractivity; Phase-affecting properties, e.g. optical path length
G01N 21/64 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
CPC
B82Y 15/00
BPERFORMING OPERATIONS; TRANSPORTING
82NANOTECHNOLOGY
YSPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
15Nanotechnology for interacting, sensing or actuating, e.g. quantum dots as markers in protein assays or molecular motors
C01B 33/02
CCHEMISTRY; METALLURGY
01INORGANIC CHEMISTRY
BNON-METALLIC ELEMENTS; COMPOUNDS THEREOF; ; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
33Silicon; Compounds thereof
02Silicon
C09K 11/59
CCHEMISTRY; METALLURGY
09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
KMATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
11Luminescent, e.g. electroluminescent, chemiluminescent materials
08containing inorganic luminescent materials
59containing silicon
G01N 21/41
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
17Systems in which incident light is modified in accordance with the properties of the material investigated
41Refractivity; Phase-affecting properties, e.g. optical path length
G01N 21/64
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
G01N 33/543
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
Applicants
  • パナソニックIPマネジメント株式会社 PANASONIC INTELLECTUAL PROPERTY MANAGEMENT CO., LTD. [JP]/[JP]
Inventors
  • 柳川 博人 YANAGAWA Hiroto
Agents
  • 鎌田 健司 KAMATA Kenji
  • 野村 幸一 NOMURA Koichi
Priority Data
2018-22505330.11.2018JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) COMPLEX AND DETECTION DEVICE
(FR) COMPLEXE ET DISPOSITIF DE DÉTECTION
(JA) 複合体及び検出装置
Abstract
(EN)
The present invention provides a complex having excellent dispersibility and stable light-emitting properties. The complex (2032) contains a first substance (20322) having the property of binding specifically to a target substance, a quantum dot (20321a) containing silicon as the main component and having a negatively charged surface, and a linker substance (20321b) containing the compound represented by general formula (1) and covering the surface of the quantum dot (20321a), the first substance (20322) being fixed onto the surface of the quantum dot (20321a) via the linker substance (20321b). (1) X-L-Si-(R1)(R2)(OR3) (In the formula, X represents a basic functional group, R1, R2, and R3 each independently represent an alkyl group, and L represents an alkylene group)
(FR)
La présente invention concerne un complexe ayant une excellente capacité de dispersion et des propriétés d'émission de lumière stables. Le complexe (2032) contient une première substance (20322) ayant la propriété de se lier spécifiquement à une substance cible, un point quantique (20321a) contenant du silicium en tant que constituant principal et ayant une surface chargée négativement, et une substance de liaison (20321b) contenant le composé représenté par la formule générale (1) et recouvrant la surface du point quantique (20321a), la première substance (20322) étant fixée sur la surface du point quantique (20321a) par l'intermédiaire de la substance de liaison (20321b). (1) X-L-Si-(R1)(R2)(OR3) (Dans la formule, X représente un groupe fonctionnel basique, R1, R2, et R3 représentent chacun indépendamment un groupe alkyle, et L représente un groupe alkylène)
(JA)
本開示は、良好な分散性と安定な発光特性とを有する複合体を提供する。本開示による複合体(2032)は、標的物質と特異的に結合する性質を有する第1物質(20322)と、シリコンを主成分として含み、かつ、表面が負の電荷を帯びている量子ドット(20321a)と、下記一般式(1)で表される化合物を含み、量子ドット(20321a)の表面を覆うリンカー物質(20321b)と、を含み、第1物質(20322)は、リンカー物質(20321b)を介して量子ドット(20321a)の表面に固定化される。 X-L-Si-(R)(R)(OR) ・・・(1) (ただし、式中、Xは、塩基性の官能基であり、R、R、及び、Rは、それぞれ独立して、アルキル基であり、Lは、アルキレン基である。)
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