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1. WO2020110152 - NON-PEPTIDIC GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONISTS AND METHOD OF PREPARATION THEREOF

Publication Number WO/2020/110152
Publication Date 04.06.2020
International Application No. PCT/IN2019/050874
International Filing Date 29.11.2019
IPC
A61K 31/498 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
498Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
C07D 459/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
459Heterocyclic compounds containing benz indolo quinolizine ring systems, e.g. yohimbine; 16, 18-lactones thereof, e.g. reserpic acid lactone
C07D 403/06 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
A61P 3/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
CPC
A61K 31/498
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
498Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
A61P 3/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
C07D 403/06
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
06linked by a carbon chain containing only aliphatic carbon atoms
C07D 459/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
459Heterocyclic compounds containing benz [g] indolo [2, 3-a] quinolizine ring systems, e.g. yohimbine; 16, 18-lactones thereof, e.g. reserpic acid lactone
Applicants
  • GIRDHAR, Khyati [IN]/[IN]
  • GAUR, Pankaj [IN]/[IN]
  • MONDAL, Prosenjit [IN]/[IN]
Inventors
  • GIRDHAR, Khyati
  • GAUR, Pankaj
  • MONDAL, Prosenjit
Agents
  • SRIHARI, Saragur, Kasturirangan
  • PANDEY, Shachindra Kumar
  • ARORA, Kavita
  • KHURANA, Shweta
  • SHIKHA, Singh
  • KUMARI, Jyoti
Priority Data
20181104502329.11.2018IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NON-PEPTIDIC GLUCAGON-LIKE PEPTIDE-1 RECEPTOR AGONISTS AND METHOD OF PREPARATION THEREOF
(FR) AGONISTES NON PEPTIDIQUES DU RÉCEPTEUR DU PEPTIDE-1 DE TYPE GLUCAGON ET LEUR PROCÉDÉ DE PRÉPARATION
Abstract
(EN)
The present invention provides novel compounds, which specifically bind with GLP-1R and which have beneficial effects as therapeutics for diabetes and other metabolic diseases. The present invention also describes the process of synthesis of said novel compound and its ability to bind with GLP-1R.
(FR)
La présente invention concerne de nouveaux composés qui se lient spécifiquement au GLP-1R et qui ont des effets bénéfiques en tant qu'agents thérapeutiques contre le diabète et d'autres maladies métaboliques. La présente invention concerne également le procédé de synthèse dudit nouveau composé et de sa capacité à se lier au GLP-1R.
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