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1. WO2020110146 - PROCESS FOR THE PREPARATION OF HIGH PURE ERIBULIN AND ITS MESYLATE SALT

Publication Number WO/2020/110146
Publication Date 04.06.2020
International Application No. PCT/IN2019/050868
International Filing Date 27.11.2019
IPC
A61K 31/357 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
335having oxygen as the only ring hetero atom, e.g. fungichromin
357having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel
CPC
C07C 311/19
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
311Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
15Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
16having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
19to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
C07D 493/22
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
493Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
22in which the condensed system contains four or more hetero rings
Applicants
  • NATCO PHARMA LIMITED [IN]/[IN]
Inventors
  • DIVYA, Prabhakar
  • KASA, Srinivasu
  • KONAKANCHI, Durga Prasad
  • DANDALA, Ramesh
  • MUDDASANI, Pulla Reddy
  • NANNAPANENI, Venkaiah Chowdary
Priority Data
20184104487728.11.2018IN
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESS FOR THE PREPARATION OF HIGH PURE ERIBULIN AND ITS MESYLATE SALT
(FR) PROCÉDÉ POUR LA PRÉPARATION D'ÉRIBULINE DE HAUTE PURETÉ ET DE SON SEL DE MÉSYLATE
Abstract
(EN)
The present invention relates to a process for the preparation of high pure Eribulin and Eribulin Mesylate. The present invention involves preparation of high pure Eribulin and its mesylate salt involving chiral acid addition salts of Eribulin.
(FR)
La présente invention concerne un procédé de préparation d'Éribuline de haute pureté et d'Éribuline Mésylate. La présente invention concerne la préparation d'Éribuline de haute pureté et de son sel de mésylate impliquant des sels d'addition d'acide chiraux d'Éribuline.
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