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1. WO2020110108 - PURIFICATION OF MAGNESIUM LACTATE FROM FERMENTATION BROTHS HAVING HIGH AMOUNTS OF IMPURITIES

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[ EN ]

CLAIMS

1. A process for the separation and purification of magnesium lactate from a fermentation broth, comprising the steps of:

(a) providing a clarified fermentation broth from which insoluble impurities have been removed comprising magnesium lactate in a soluble form being the result of a fermentation process, the fermentation broth being at a temperature of about 45 °C to about 75 °C;

(b) concentrating the clarified broth from step (a) to a concentration of about 150 g/L to about 220 g/L of lactate;

(c) performing at least one cooling crystallization of the concentrated clarified broth from step (b) to obtain magnesium lactate crystals; and

(d) collecting the magnesium lactate crystals obtained.

2. The process according to claim 1, wherein the insoluble impurities comprise at least one of insoluble organic -based impurities, insoluble inorganic-based impurities and soluble impurities.

3. The process according to any one of claims 1 and 2, wherein the fermentation broth at step (a) is at a temperature of about 55 °C to about 65 °C.

4. The process according to any one of claims 1-3, wherein the separation of insoluble impurities comprises at least one technique selected from: filtration, centrifugation, flotation, sedimentation, flocculation and decantation.

5. The process according to any one of claims 1-4, wherein the separation of insoluble impurities comprises centrifugation.

6. The process according to any one of claims 1-5, wherein the separation of insoluble impurities further comprises microfiltration.

7. The process according to any one of claims 1-6, wherein the separation of insoluble impurities comprises centrifugation and microfiltration.

8. The process according to any one of claims 1-7, wherein the concentration at step (b) is performed by evaporation, nanofiltration, reverse osmosis, or

combinations thereof.

9. The process according to any one of claims 1-8, wherein the broth at step (b) is concentrated to a concentration of about 160 g/L to about 220 g/L of lactate.

10. The process according to claim 9, wherein the broth at step (b) is concentrated to a concentration of about 170 g/L to about 220 g/L of lactate.

11. The process according to claim 10, wherein the broth at step (b) is concentrated to a concentration of about 180 g/L to about 220 g/L of lactate.

12. The process according to any one of claims 1-11, wherein at step (c) the at least one cooling crystallization begins at a first temperature selected from the range of about 50 to about 75 °C.

13. The process according to claim 12, wherein at step (c) the at least one cooling crystallization begins at a first temperature selected from the range of about 50 to about 70 °C.

14. The process according to claim 13, wherein at step (c) the at least one cooling crystallization begins at a first temperature selected from the range of about 50 to about 65 °C.

15. The process according to any one of claims 1-14, wherein at step (c) the at least one cooling crystallization step ends at a second temperature selected from the range of about 10 to about 1 °C.

16. The process according to claim 15, wherein at step (c) the at least one cooling crystallization ends at a second temperature selected from the range of about 6 to about 2 °C.

17. The process according to any one of claims 1-16, wherein at step (c) the cooling rate of the at least one cooling crystallization is in the range of about 10 to about 0.5 °C/h.

18. The process according to claim 17, wherein at step (c) the cooling rate of the at least one cooling crystallization is in the range of about 5 to about 1 °C/h.

19. The process according to any one of claims 1-18, wherein at step (c) before the at least one cooling crystallization, the pH of the concentrated clarified broth is in the range of about 6 to about 7.

20. The process according to any one of claims 1-19, wherein the obtained magnesium lactate crystals at step (d) are separated from the remaining liquid by a method selected from microfiltration and nanofiltration.

21. The process according to claim 20, wherein the remaining liquid from step (c) undergoes concentration, followed by at least one additional crystallization, in order to obtain additional magnesium lactate crystals.

22. The process according to claim 21, wherein the additional obtained magnesium lactate crystals are separated from the liquid.

23. The process according to any one of claims 1-22 wherein the obtained magnesium lactate crystals from claim 20 are combined with the additional obtained magnesium lactate crystals from claim 22, thus forming combined magnesium lactate crystals.

24. The process according to any one of claims 1-20 or claim 23, further comprising step (e): washing and/or purifying the obtained magnesium lactate crystals or the combined magnesium lactate crystals.

25. The process according to claim 24, wherein step (e) comprises washing and/or purifying the obtained magnesium lactate crystals or the combined magnesium lactate crystals, utilizing an organic solvent selected from the group consisting of: ethanol, propanol, isobutanol, cyclohexane, acetone, ethyl acetate and combinations thereof.

26. The process according to claim 24, wherein step (e) comprises washing and/or purifying the obtained magnesium lactate crystals or the combined magnesium lactate crystals with an aqueous solution.

27. The process according to any one of claims 24-26, wherein the solvent or the solution in step (f) has a specific temperature selected from about 0.5 to about 8 °C.

28. The process according to any one of claims 24-27, wherein step (e) further comprises at least one polishing step, selected from extraction, microfdtration, nanofiltration, active carbon treatment, distillation, drying and grinding.

29. The process according to any one of claims 24-28, wherein step (e) further comprises packaging for transportation purposes.