Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020110011 - CYCLIC PEPTIDES AS PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDERS

Publication Number WO/2020/110011
Publication Date 04.06.2020
International Application No. PCT/IB2019/060203
International Filing Date 26.11.2019
IPC
C07K 7/08 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
08having 12 to 20 amino acids
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 3/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3Drugs for disorders of the metabolism
06Antihyperlipidemics
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
C07K 7/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
7Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
04Linear peptides containing only normal peptide links
08having 12 to 20 amino acids
Applicants
  • NOVARTIS AG [CH]/[CH]
Inventors
  • FLYER, Alec Nathanson
  • GOLOSOV, Andrei Alexandrovich
  • GROSCHE, Philipp
  • LEWIS, Ian
  • LIU, Eugene Yuejin
  • MARZINZIK, Andreas
  • MONOVICH, Lauren Gilchrist
  • OTTL, Johannes
  • PATEL, Tajesh Jayprakash
  • REID, Patrick Crawford
  • SEEPERSAUD, Mohindra
Agents
  • NOVARTIS AG
Priority Data
62/772,03327.11.2018US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CYCLIC PEPTIDES AS PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 (PCSK9) INHIBITORS FOR THE TREATMENT OF METABOLIC DISORDERS
(FR) PEPTIDES CYCLIQUES SERVANT D'INHIBITEURS DE PROPROTÉINE CONVERTASE SUBTILISINE/KEXINE DE TYPE 9 (PCSK9) POUR LE TRAITEMENT DE TROUBLES MÉTABOLIQUES
Abstract
(EN)
The disclosure relates to inhibitors of PCSK9 useful in the treatment of lipid metabolism, and other diseases in which PCSK9 plays a role, having the Formula (I): or a pharmaceutically acceptable salt, hydrate, solvate, stereoisomer, or tautomer thereof, wherein R1, X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12, and X13 are described herein.
(FR)
L'invention concerne des inhibiteurs de PCSK9 utiles dans le traitement du métabolisme lipidique, et d'autres maladies dans lesquelles PCSK9 joue un rôle, ayant la formule (I) : X13 X12 X11 X10 X9 X8 X7 X6 X5 X4 X3 X2HNSOX1 NHR1O (I), ou un sel, un hydrate, un solvate, un stéréoisomère ou un tautomère pharmaceutiquement acceptable de ceux-ci, dans la formule, R1, X1, X2, X3, X4, X5, X6, X7, X8, X9, X10, X11, X12 et X13 sont tels que définis dans la description.
Latest bibliographic data on file with the International Bureau