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1. WO2020109965 - COLLYRIUM CONTAINING CITRUS EXTRACT IN LIPOSOMAL FORM

Publication Number WO/2020/109965
Publication Date 04.06.2020
International Application No. PCT/IB2019/060123
International Filing Date 25.11.2019
IPC
A61K 9/127 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
A61K 47/38 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
38Cellulose; Derivatives thereof
A61K 36/752 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
75Rutaceae (Rue family)
752Citrus, e.g. lime, orange or lemon
A61K 8/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
8Cosmetics or similar toilet preparations
CPC
A61K 36/752
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18Magnoliophyta (angiosperms)
185Magnoliopsida (dicotyledons)
75Rutaceae (Rue family)
752Citrus, e.g. lime, orange or lemon
A61K 47/38
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
38Cellulose; Derivatives thereof
A61K 9/0048
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0048Eye, e.g. artificial tears
A61K 9/127
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
Applicants
  • OFFHEALTH S.P.A. [IT]/[IT]
Inventors
  • ZANINI, Alessandro
  • VELLANTE, Marco
  • SODO, Eugenio
  • CAVALLO, Giovanni
  • FOSCHINI, Fulvio
  • GIUVA, Roberto
Agents
  • SARPI, Maurizio
  • FEZZARDI, Antonio
Priority Data
10201800001057626.11.2018IT
Publication Language English (EN)
Filing Language Italian (IT)
Designated States
Title
(EN) COLLYRIUM CONTAINING CITRUS EXTRACT IN LIPOSOMAL FORM
(FR) COLLYRE CONTENANT UN EXTRAIT D'AGRUMES SOUS FORME LIPOSOMALE
Abstract
(EN)
An ophthalmic preparation consisting of an aqueous solution, or collyrium, containing a dispersion of BIOSECUR® liposomes of a mixture containing flavonoid- rich citrus extracts, in the form of a liposomal preparation, provides excellent antibacterial protection, in the parameters indicated by the A classification of the Pharmacopoeia XII ed. Preferably, such a collyrium, in borate isotonic buffer, is made viscous to improve its stability and mucoadhesiveness, with the addition of hydroxypropy1-methylcellulose (hypromellose). A method is also described for preparing such a solution for ophthalmic use comprising Biosecur® or a composition based on flavonoid-rich citrus extracts, in liposomal form, wherein the liposomes have a size smaller than 200 nm.
(FR)
L'invention porte sur une préparation ophtalmique constituée d'une solution aqueuse, ou d'un collyre, contenant une dispersion de liposomes BIOSECUR® d'un mélange contenant des extraits d'agrumes riches en flavonoïdes, sous la forme d'une préparation liposomale, qui fournit une excellente protection antibactérienne, selon les paramètres indiqués par la classification de la pharmacopée XII éd, de péférence, un tel collyrium, dans un tampon isotonique à base de borate, est rendu visqueux pour améliorer sa stabilité et la mucoadhésivité, avec l'ajout d'hydroxypropy1-méthylcellulose (hyprothése). L'invention porte également un procédé de préparation d'une telle solution à usage ophtalmique comprenant du Biosecur® ou une composition à base d'extraits d'agrumes riches en flavonoïdes, sous forme liposomale, les liposomes ayant une taille inférieure à 200 nm.
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