Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020109836 - METHOD FOR THE MODIFICATION OF A DEVICE SURFACE BY GRAFTING A CD31-DERIVED PEPTIDE ONTO THE SURFACE OF SAID DEVICE

Publication Number WO/2020/109836
Publication Date 04.06.2020
International Application No. PCT/IB2018/001498
International Filing Date 27.11.2018
IPC
A61L 31/02 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles
02Inorganic materials
A61L 31/10 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles
08Materials for coatings
10Macromolecular materials
A61L 31/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles
14Materials characterised by their function or physical properties
16Biologically active materials, e.g. therapeutic substances
CPC
A61L 31/022
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles ; , e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
02Inorganic materials
022Metals or alloys
A61L 31/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles ; , e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
08Materials for coatings
10Macromolecular materials
A61L 31/16
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
31Materials for other surgical articles ; , e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
14Materials characterised by their function or physical properties ; , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
16Biologically active materials, e.g. therapeutic substances
Applicants
  • BALT EXTRUSION [FR]/[FR]
  • INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) [FR]/[FR]
  • UNIVERSITE PARIS 13 - PARIS NORD [FR]/[FR]
  • UNIVERSITÉ PARIS DIDEROT - PARIS 7 [FR]/[FR]
Inventors
Agents
  • COLOMBIE, Damien
  • BLOT, Philippe
  • DOMENEGO, Bertrand
  • HABASQUE, Etienne
  • HOLTZ, Béatrice
  • NEYRET, Daniel
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR THE MODIFICATION OF A DEVICE SURFACE BY GRAFTING A CD31-DERIVED PEPTIDE ONTO THE SURFACE OF SAID DEVICE
(FR) PROCÉDÉ POUR LA MODIFICATION DE LA SURFACE D'UN DISPOSITIF PAR GREFFAGE D'UN PEPTIDE DÉRIVÉ DU CD31 SUR LA SURFACE DUDIT DISPOSITIF
Abstract
(EN)
The present invention relates to a method for the modification of the surface of a metallic implantable device for interventional neuroradiology by grafting a CD31 - derived peptide onto the surface of said device, wherein the CD31 -derived peptide consists of a sequence selected from the group consisting of: SEQ ID NO: 2 to 8, SEQ ID NO: 12 to 79, and SEQ ID NO: 81, said method comprising the following steps: a) the coating of a polydopamine layer onto the surface of the device in order to obtain a polydopamine coated surface; b) the modification of the polydopamine coated surface by the addition of a linker comprising at least one reactive moiety chosen from alkyne functions, in order to obtain a modified polydopamine coated surface; and c) the addition of a CD31 -derived peptide comprising an azide terminal group and its reaction with the alkyne function of the linker of step b), in order to obtain a polydopamine coated surface grafted by a CD31-derived peptide.
(FR)
La présente invention concerne un procédé pour la modification de la surface d'un dispositif métallique implantable pour neuroradiologie interventionnelle par greffage d'un peptide dérivé du CD31 sur la surface dudit dispositif, le peptide dérivé du CD31 étant constitué d'une séquence choisie dans le groupe constitué par : SEQ ID NO : 2 à 8, SEQ ID NO : 12 À 79 et SEQ ID NO : 81. Ledit procédé comprend les étapes suivantes : a) le revêtement à l'aide d'une couche de polydopamine de la surface du dispositif pour obtenir une surface revêtue de polydopamine ; b) la modification de la surface revêtue de polydopamine par l'addition d'une séquence de liaison comprenant au moins une fraction réactive choisie parmi les fonctions alcyne, afin d'obtenir une surface revêtue de polydopamine modifiée ; et c) l'addition d'un peptide dérivé du CD31 comprenant un groupe terminal azide et sa réaction avec la fonction alcyne de la séquence de liaison de l'étape b), afin d'obtenir une surface revêtue de polydopamine greffée à l'aide d'un peptide dérivé du CD31.
Latest bibliographic data on file with the International Bureau