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1. WO2020109625 - COMBINED TREATMENT OF PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA


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INTERNATIONAL SEARCH REPORT (ISR)
Part 1:  1  2  3  4  5  6          Part 2:  A  B  C  D  E 
International application No. Applicant's or agent's file reference
PCT/EP2019/083322 PCT141713
International filing date (day/month/year) (Earliest) Priority Date (day/month/year)
02 December 2019 30 November 2018
Applicant
FONDAZIONE CENTRO SAN RAFFAELE
FOR FURTHER ACTION: See Form PCT/ISA/220 as well as, where applicable, item 5 below.
This international search report has been prepared by this International Searching Authority and is transmitted to the applicant according to Article 18. A copy is being transmitted to the International Bureau.
It is also accompanied by a copy of each prior art document cited in this report.
1. Basis of the report
a. With regard to the language, the international search was carried out on the basis of:
the international application in the language in which it was filed.
a translation of the international application into                                          which is the language of a translation furnished for the purposes of international search (Rules 12.3(a) and 23.1(b)).
b.
This international search report has been established taking into account the rectification of an obvious mistake authorized by or notified to this Authority under Rule 91 (Rule 43.6bis(a)).
c.
1. With regard to any nucleotide and/or amino acid sequence disclosed in the international application, the international search was carried out on the basis of a sequence listing:
a. forming part of the international application as filed:
in the form of an Annex C/ST.25 text file.
on paper or in the form of an image file.
b. furnished together with the international application under PCT Rule 13ter.1(a) for the purposes of international search only in the form of an Annex C/ST.25 text file.
c. furnished subsequent to the international filing date for the purposes of international search only:
in the form of an Annex C/ST.25 text file (Rule 13ter.1(a)).
on paper or in the form of an image file (Rule 13ter.1(b) and Administrative Instructions, Section 713).
2.
In addition, in the case that more than one version or copy of a sequence listing has been filed or furnished, the required statements that the information in the subsequent or additional copies is identical to that forming part of the application as filed or does not go beyond the application as filed, as appropriate, were furnished.
3.
Additional comments:
2. Certain claims were found unsearchable
3. Unity of invention is lacking
4. Title of the invention
The text is approved as submitted by the applicant.
The text has been established by this Authority to read as follows:
5. Abstract
The text is approved as submitted by the applicant.
The text has been established, according to Rule 38.2, by this Authority as it appears in Box No. IV. The applicant may, within one month from the date of mailing of this international search report, submit comments to this Authority.
6. Drawings
a.
The figure of the drawings to be published with the abstract is Figure No. ____________
as suggested by the applicant.
as selected by this Authority, because the applicant failed to suggest a figure.
as selected by this Authority, because this figure better characterizes the invention.
b.
none of the figures is to be published with the abstract.

A. CLASSIFICATION OF SUBJECT MATTER

     A61K 31/00 (2006.01)i; A61K 38/19 (2006.01)i; A61K 39/395 (2006.01)i; A61P 35/00 (2006.01)i
According to International Patent Classification (IPC) or to both national classification and IPC

B. FIELDS SEARCHED

Minimum documentation searched (classification system followed by classification symbols):
     A61K; C07K; A61P
Documentation searched other than minimum documentation to the extent that such documents are included in the fields searched:
Electronic data base consulted during the international search (name of data base and, where practicable, search terms used):
EPO-Internal, BIOSIS, EMBASE, WPI Data

C. DOCUMENTS CONSIDERED TO BE RELEVANT

Category* Citation of document, with indication, where appropriate, of the relevant passages Relevant to claim No.
(1)
X
FERRERI ANDRES J M ET AL, "R-CHOP Preceded By Engineered Tumor Necrosis Factor (TNF) in Patients with Relapsed or Refractory (r/r) Primary CNS Lymphoma (PCNSL): Results of Antitumor Activity, Safety and Blood-Brain Barrier (BBB) Permeabilization in the "Ingrid" Phase II Trial", BIOSIS29 November 2018 (2018-11-29), Database accession no. PREV201900317358
Retrieved from the Internet:
URL:BIOSCIENCES INFORMATION SERVICE, PHILADELPHIA, PA, US
XP002798112
1,3-5,7
Y
abstract
1-7
& BLOOD,Vol. 132, No. Suppl. 1, 29 November 2018 (2018-11-29), page 1687,
(2)
Y
AU 2008207357 A1 (BIOGEN IDEC INC) 04 September 2008 (2008-09-04)
1-7
pages 23,30
(3)
Y
US 2015246123 A1 (DOSHI PARUL [US]) 03 September 2015 (2015-09-03)
1-7
paragraphs [0013] - [0018]
(4)
Y
EP 2364995 A1 (MOLMED SPA [IT]; SAN RAFFAELE CENTRO FOND [IT]) 14 September 2011 (2011-09-14)
1-7
paragraphs [0012], [0019] - [0022], [0199], [0205]
*
Special categories of cited documents:
"A"
document defining the general state of the art which is not considered to be of particular relevance
"D"
document cited by the applicant in the international application
"E"
earlier application or patent but published on or after the international filing date
"L"
document which may throw doubts on priority claim(s) or which is cited to establish the publication date of another citation or other special reason (as specified)
"O"
document referring to an oral disclosure, use, exhibition or other means
"P"
document published prior to the international filing date but later than the priority date claimed
"T"
later document published after the international filing date or priority date and not in conflict with the application but cited to understand the principle or theory underlying the invention
"X"
document of particular relevance; the claimed invention cannot be considered novel or cannot be considered to involve an inventive step when the document is taken alone
"Y"
document of particular relevance; the claimed invention cannot be considered to involve an inventive step when the document is combined with one or more other such documents, such combination being obvious to a person skilled in the art
"&"
document member of the same patent family

D. INFORMATION ON PATENT FAMILY MEMBERS

Patent document cited in search report Publication date
(day/month/year)
Patent family member(s) Publication date
(day/month/year)
AU 2008207357 A1
04 September 2008
AT 414536 T
AU 767965 B2
AU 2004200806 A1
AU 2008207357 A1
BR 9913645 A
CA 2340091 A1
CN 1320044 A
CN 1689644 A
CN 1689645 A
CN 1689646 A
CN 101695574 A
CY 1108906 T1
CY 1113600 T1
CZ 303898 B6
DK 1112084 T3
DK 1974747 T3
EA 200100224 A1
EP 1112084 A1
EP 1946775 A2
EP 1974747 A1
EP 2260866 A1
EP 2263693 A1
EP 2275136 A1
EP 2990054 A1
ES 2317702 T3
ES 2388893 T3
HK 1083444 A1
HK 1083449 A1
HK 1122511 A1
HU 0103484 A2
IL 141349 A
IL 207358 A
JP 6226216 B2
JP 6241794 B2
JP 6253842 B2
JP 2002522511 A
JP 2009173686 A
JP 2010265318 A
JP 2013227352 A
JP 2015098486 A
JP 2017128615 A
JP 2017214435 A
JP 2017222727 A
JP 2019065023 A
KR 20010072388 A
KR 20080038453 A
KR 20090014243 A
KR 20090115895 A
KR 20110022097 A
MX PA01001530 A
MY 136203 A
NO 332893 B1
NZ 528199 A
NZ 573838 A
PL 346046 A1
PT 1112084 E
PT 1974747 E
TW I242444 B
TW I322014 B
TW 200846021 A
TW 201106974 A
US 6455043 B1
US 2003026804 A1
US 2003206903 A1
US 2008038261 A1
US 2012251534 A1
US 2012251535 A1
US 2012258101 A1
US 2012258102 A1
US 2013273039 A1
US 2014056887 A1
US 2015183882 A1
US 2016333106 A1
US 2017037140 A1
WO 0009160 A1
ZA 200101157 B
15 December 2008
27 November 2003
25 March 2004
04 September 2008
25 September 2001
24 February 2000
31 October 2001
02 November 2005
02 November 2005
02 November 2005
21 April 2010
02 July 2014
22 June 2016
19 June 2013
16 March 2009
17 September 2012
27 August 2001
04 July 2001
23 July 2008
01 October 2008
15 December 2010
22 December 2010
19 January 2011
02 March 2016
16 April 2009
19 October 2012
08 May 2009
11 June 2010
18 January 2013
28 January 2002
28 June 2012
28 September 2017
08 November 2017
06 December 2017
27 December 2017
23 July 2002
06 August 2009
25 November 2010
07 November 2013
28 May 2015
27 July 2017
07 December 2017
21 December 2017
25 April 2019
31 July 2001
06 May 2008
06 February 2009
09 November 2009
04 March 2011
24 April 2002
29 August 2008
28 January 2013
24 June 2005
28 January 2011
14 January 2002
20 February 2009
05 September 2012
01 November 2005
21 March 2010
01 December 2008
01 March 2011
24 September 2002
06 February 2003
06 November 2003
14 February 2008
04 October 2012
04 October 2012
11 October 2012
11 October 2012
17 October 2013
27 February 2014
02 July 2015
17 November 2016
09 February 2017
24 February 2000
10 July 2002
US 2015246123 A1
03 September 2015
AU 2015223205 A1
BR 112016019866 A2
CA 2940864 A1
CL 2016002158 A1
CN 106459184 A
CR 20160388 A
DK 3110843 T3
DO P2016000224 A
EA 201691747 A1
EP 3110843 A1
GT 201600172 A
HR P20192058 T1
HU E046028 T2
JP 2017507953 A
KR 20160126026 A
LT 3110843 T
PE 20161175 A1
PH 12016501700 A1
PL 3110843 T3
PT 3110843 T
SG 11201607028X A
SI 3110843 T1
SV 2016005267 A
US 2015246123 A1
US 2017174780 A1
WO 2015130728 A1
ZA 201708541 B
08 September 2016
17 October 2017
03 September 2015
28 July 2017
22 February 2017
07 November 2016
11 November 2019
31 March 2017
31 May 2017
04 January 2017
15 August 2019
21 February 2020
28 January 2020
23 March 2017
01 November 2016
11 November 2019
03 November 2016
03 October 2016
28 February 2020
19 November 2019
29 September 2016
29 November 2019
18 January 2017
03 September 2015
22 June 2017
03 September 2015
28 November 2018
EP 2364995 A1
14 September 2011
AU 2005317684 A1
CA 2593964 A1
CN 101124243 A
EA 200701053 A1
EP 1831254 A2
EP 2364995 A1
ES 2388068 T3
HK 1106781 A1
IL 183710 A
JP 2008525424 A
KR 20070102684 A
US 2009068106 A1
US 2011076234 A1
WO 2006067633 A2
29 June 2006
29 June 2006
13 February 2008
30 June 2008
12 September 2007
14 September 2011
08 October 2012
21 December 2012
31 January 2012
17 July 2008
19 October 2007
12 March 2009
31 March 2011
29 June 2006
Name and mailing address of the ISA/:
European Patent Office
P.B. 5818, Patentlaan 2, 2280 HV Rijswijk,
Netherlands
Telephone No. (+31-70)340-2040
Facsimile No. (+31-70)340-3016
Date of the actual completion of the international search:
16 March 2020
Date of mailing of the international search report:
30 March 2020
Authorized officer:
Zellner, Eveline
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