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1. WO2020109570 - METHOD FOR PREDICTING THE RESPONSE TO CANCER IMMUNOTHERAPY IN CANCER PATIENTS

Publication Number WO/2020/109570
Publication Date 04.06.2020
International Application No. PCT/EP2019/083124
International Filing Date 29.11.2019
IPC
C12Q 1/6886 2018.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
CPC
C12Q 1/6886
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
6883for diseases caused by alterations of genetic material
6886for cancer
C12Q 2600/106
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
C12Q 2600/158
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
2600Oligonucleotides characterized by their use
158Expression markers
Applicants
  • GBG FORSCHUNGS GMBH [DE]/[DE]
  • CHARITÉ - UNIVERSITÄTSMEDIZIN BERLIN [DE]/[DE]
Inventors
  • DENKERT, Carsten
  • SINN, Bruno
  • LOIBL, Sibylle
  • WEBER, Karsten
  • KARN, Thomas
Agents
  • VOSSIUS & PARTNER (NO 31)
Priority Data
18209672.730.11.2018EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) METHOD FOR PREDICTING THE RESPONSE TO CANCER IMMUNOTHERAPY IN CANCER PATIENTS
(FR) MÉTHODE DE PRÉDICTION DE LA RÉPONSE À UNE IMMUNOTHÉRAPIE ANTICANCÉREUSE CHEZ DES PATIENTS ATTEINTS D'UN CANCER
Abstract
(EN)
The present invention relates to methods, kits, systems and uses thereof for prediction of the response or resistance to and/or benefit from a cancer immunotherapy of a subject suffering from or being at risk of developing a neoplastic disease, in particular breast cancer, based on the measurement(s) of expression level(s) of at least one marker in samples of said subject. Equally, the present invention relates to methods, kits, systems and uses thereof for predicting the outcome from the cancer immunotherapy treatment in said subject based on the measurement(s) of the expression level(s) of the at least one marker in samples of said subject. Further, the present invention relates to the cancer immunotherapy for use in the treatment of the neoplastic disease, in particular breast cancer, in the subject and to methods for cancer immunotherapy treatment by using the cancer immunotherapy according to the methods of the present invention.
(FR)
La présente invention concerne des méthodes, des kits, des systèmes et des utilisations correspondantes pour la prédiction de la réponse ou de la résistance à et/ou des bienfaits bénéficier d'une immunothérapie anticancéreuse chez sujet souffrant ou présentant un risque de développer une maladie néoplasique, en particulier un cancer du sein, sur la base de la(des) mesure(s) du(des) niveau(x) d'expression d'au moins un marqueur dans des échantillons dudit sujet. La présente invention concerne également des méthodes, des kits, des systèmes et des utilisations correspondantes pour prédire le résultat du traitement d'immunothérapie anticancéreuse chez ledit sujet sur la base de la(des) mesure(s) du(des) niveau(x) d'expression d'au moins un marqueur dans des échantillons dudit sujet. En outre, la présente invention concerne l'immunothérapie anticancéreuse destinée à être utilisée dans le traitement de la maladie néoplasique, en particulier du cancer du sein, chez le sujet et des méthodes de traitement d'immunothérapie anticancéreuse utilisant l'immunothérapie anticancéreuse selon les méthodes de la présente invention.
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