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1. WO2020109420 - PROCESSES FOR PREPARING NITROSYLATED PROPANEDIOLS, COMPOSITIONS COMPRISING THE SAME, AND MEDICAL USES THEREOF

Publication Number WO/2020/109420
Publication Date 04.06.2020
International Application No. PCT/EP2019/082800
International Filing Date 27.11.2019
IPC
A61K 31/21 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
A61P 9/12 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
12Antihypertensives
C07C 201/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
201Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
04Preparation of esters of nitrous acid
C07C 203/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
203Esters of nitric or nitrous acid
CPC
A61K 31/21
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
A61P 9/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
12Antihypertensives
C07B 2200/07
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
2200Indexing scheme relating to specific properties of organic compounds
07Optical isomers
C07B 43/02
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
43Formation or introduction of functional groups containing nitrogen
02of nitro or nitroso groups
C07C 201/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
201Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
04Preparation of esters of nitrous acid
C07C 203/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
203Esters of nitric or nitrous acid
Applicants
  • ATTGENO AB [SE]/[SE]
Inventors
  • AGVALD, Per Håkan
  • ADDING, Leif Christofer
  • NILSSON, Kristofer Bo Ingemar
  • MINIDIS, Anna Lena Elisabeth
  • MALMBERG, Johan Salman
  • MINIDIS, Alexander Bogdan Emil
Agents
  • PROCTOR, Anthony James
Priority Data
1819298.927.11.2018GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PROCESSES FOR PREPARING NITROSYLATED PROPANEDIOLS, COMPOSITIONS COMPRISING THE SAME, AND MEDICAL USES THEREOF
(FR) PROCÉDÉS DE PRÉPARATION DE PROPANEDIOLS NITROSYLÉS, COMPOSITIONS COMPRENANT CEUX-CI, ET LEURS UTILISATIONS MÉDICALES
Abstract
(EN)
The present invention relates to a novel process for the synthesis of mono- and bis-nitrosylated propanediols, as well as novel compositions and pharmaceutical formulations comprising said compounds. The process proceeds by reacting a corresponding propanediol that is not nitrosylated with a source of nitrite, optionally in the presence of a suitable acid. Wherein, when the source of nitrite is an organic nitrite, reacting step is performed in a suitable organic solvent, and when the source of nitrite is an inorganic nitrite, the reacting step is performed in a bi-phasic solvent mixture comprising an aqueous phase and a non-aqueous phase. The invention also relates to methods of treating a condition wherein administration of nitric oxide (NO) has a beneficial effect by administering said compounds, compositions or formulations.
(FR)
La présente invention concerne un nouveau procédé de synthèse de propanediols mononitrosylés et binitrosylés, ainsi que de nouvelles compositions et formulations pharmaceutiques comprenant lesdits composés. Le procédé consiste à faire réagir un propanediol correspondant qui n'est pas nitrosylé avec une source de nitrite, éventuellement en présence d'un acide approprié. Lorsque la source de nitrite est un nitrite organique, une étape de réaction est effectuée dans un solvant organique approprié, et lorsque la source de nitrite est un nitrite inorganique, l'étape de réaction est réalisée dans un mélange de solvants biphasiques comprenant une phase aqueuse et une phase non aqueuse. L'invention concerne également des méthodes de traitement d'une pathologie dans lesquelles l'administration de monoxyde d'azote (NO) a un effet bénéfique par l'administration desdits composés, desdites compositions ou desdites formulations.
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