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1. WO2020109414 - CHRISTENSENELLACEAE BACTERIA INCLUDING CHRISTENSENELLA MINUTA AND USES THEREOF

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[ EN ]

CLAIMS

1. A strain of Christensenella minuta with the deposit number DSM 32891.

2. A strain derived from the strain according to claim 1.

3. The strain according to either claim 1 or 2 in which the strain is a genetically modified mutant.

4. The strain according to any of claims 1 to 3, wherein said strain is in the form of a viable or a non-viable cell.

5. A cellular component, metabolite, secreted molecule or any combination thereof obtained from the strain according to any of claims 1 to 4.

6. A composition which comprises a strain of Christensenella minuta according to any of claims 1 to 4 or a cellular component, metabolite, secreted molecule or any combination thereof according to claim 5.

7. The composition according to claim 6, wherein the composition also comprises at least one bioactive component.

8. The composition according to either claim 6 or claim 7, wherein the composition also comprises at least one microorganism that is of a different strain than the bacterium according to any of claims 1 to 4.

9. The composition according to claim 8, wherein the microorganism is a gut bacterium or a lactic bacterium.

10. The composition according to any of claims 6 to 9, wherein said composition is a pharmaceutical composition.

11. The composition according to claim 10, wherein the composition also comprises at least one pharmaceutically acceptable vehicle and/or excipient.

12. The composition according to either claim 10 or claim 11, wherein said composition is presented in a form suitable for oral, sublingual, nasal, bronchial, lymphatic, rectal, transdermal, inhaled or parenteral administration.

13. The composition according to any of claims 6 to 9, wherein said composition is a nutritional composition.

14. The composition according to claim 13, wherein the nutritional composition is a foodstuff, a supplement, a nutraceutical, a probiotic or a synbiotic.

15. The composition according to claim 14, wherein said foodstuff is selected from the list that is made up of a milk product, plant product, meat product, aperitif, chocolate, drink or baby food.

16. The composition according to any of claims 6 to 15, wherein said composition has a concentration of the bacterium of between 104 and 1014 colony-forming units (CFU) per gram or milliliter of final composition.

17. The strain of Christensenella minuta according to any one of claims 1 to 4, a cellular component, metabolite, secreted molecule or any combination thereof according to claim 5, or a composition according to any one of claims 6 to 16, for use as a medicament or as a medicine.

18. A Christensenellaceae bacterium or a composition comprising a Christensenellaceae bacterium, for use in the prevention and/or treatment of a mood disorder and/or stress disorder and/or anxiety disorder and/or migraine.

19. A Christensenellaceae bacterium or a composition comprising a Christensenellaceae bacterium, for use as an adjuvant in treatments for mood disorders and/or stress disorders and/or anxiety disorders and/or migraines.

20. The Christensenellaceae bacterium or a composition comprising a Christensenellaceae bacterium for use according to claim 18 or 19, wherein the mood disorders are selected from the list which comprises: depression, major depression, atypical depression, typical or melancholic depression, psychotic depression, catatonic depression, pre- and post-partum depression, bipolar disorder, seasonal affective disorder, dysthymia, depressive personality disorder, double depression, unspecified depressive disorder, recurrent brief depressive disorder, minor depression, alterations of the state of mind, and mood disorder induced by substance abuse or by the use of drugs, such as drugs of abuse.

21. The Christensenellaceae bacterium for use according to claim 18 or 19, wherein said stress disorder is selected from reactive attachment disorder, disinhibited social engagement disorder, posttraumatic stress disorder (PTSD), acute stress disorder, and adjustment disorders.

22. The Christensenellaceae bacterium for use according to claim 18 or 19, wherein said anxiety disorder is selected from panic attack, panic disorder, agoraphobia, social phobia or social anxiety disorder, obsessive-compulsive disorder, post-traumatic stress disorder (ASD), generalized anxiety disorder, or acute stress disorder.

23. The Christensenellaceae bacterium or a composition comprising a

Christensenellaceae bacterium for use according to any one of claims 18 to 22, wherein said Christensenellaceae bacteria are bacteria of the genus Christensenella.

24. The Christensenellaceae bacterium or a composition comprising a

Christensenellaceae bacterium for use according to claim 23, wherein said

Christensenella bacteria are selected from the species Christensenella minuta, Christensenella timonensis, Christensenella massiliensis or any of the combinations thereof.

25. The Christensenellaceae bacterium or a composition comprising a

Christensenellaceae bacterium for use according to claim 24, wherein said

Christensenella bacteria is a Christensenella massiliensis strain with the deposit number DSM 102344 or a Christensenella timonensis strain with the deposit number DSM 102800 any of the combinations thereof.

26. The Christensenellaceae bacterium or a composition comprising a

Christensenellaceae bacterium for use according to claim 24, wherein said

Christensenella bacterium is a strain of Christensenella minuta with the deposit number DSM 32891selected from the bacterium of any one of claims 1 to 4, a strain of Christensenella minuta with the deposit number DSM 22607 or any of the combinations thereof.

27. The Christensenellaceae bacterium or a composition comprising a

Christensenellaceae bacterium for use according to any one of claims 18 to 26, wherein said Christensenellaceae bacteria are in the form of viable cells and/or in the form of non-viable cells.

28. The Christensenellaceae bacterium or a composition comprising a

Christensenellaceae bacterium for use according to any one of claims 18 to 27, wherein said Christensenellaceae bacterium comprises a 16S rRNA sequence having at least 90% identity, at least 95% identity, at least 96% identity, at least 97% identity, at least 98% identity, at least 99% identity, or at least 99.5% identity to the 16S rRNA sequence of the strain of Christensenella minuta with the deposit number DSM 32891 (SEQ. ID NO: 3), or wherein said Christensenellaceae bacterium comprises the strain of Christensenella minuta with the deposit number DSM 32891.

29. The bacterium for use according to any one of claims 17 to 28, which is for use in a subject selected from a human or a non-human animal.

30. The bacterium for use according to claim 29, wherein said non-human animal is selected from companion animals, livestock animals, zoo animals, mammals, dogs, cats, guinea pigs, ferrets, hamsters, pigs, cows, goats, sheep, horses, mice, and rats.

31. The bacterium for use according to any one of claims 17 to 30, wherein said use comprises administration of between 104 and 1014 colony-forming units (CFU) of said bacteria.

32. Use of the strain according to any one of claims 1 to 4, a cellular component, metabolite, secreted molecule or any of its combinations according to claim 5, or a composition according to any one of claims 6 to 16, for the preparation of a food.