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1. WO2020109339 - CHIMERIC RECEPTOR BINDING PROTEINS FOR USE IN BACTERIAL DELIVERY VEHICLES

Publication Number WO/2020/109339
Publication Date 04.06.2020
International Application No. PCT/EP2019/082640
International Filing Date 26.11.2019
IPC
C12N 7/00 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
A61P 31/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
CPC
A61P 31/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
C07K 2319/33
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2319Fusion polypeptide
33fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
C12N 7/00
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
Applicants
  • ELIGO BIOSCIENCE [FR]/[FR]
Inventors
  • FERNANDEZ-RODRIGUEZ, Jesus
Agents
  • CABINET BECKER ET ASSOCIES
Priority Data
62/771,76127.11.2018US
62/802,77708.02.2019US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) CHIMERIC RECEPTOR BINDING PROTEINS FOR USE IN BACTERIAL DELIVERY VEHICLES
(FR) PROTÉINES CHIMÈRES DE LIAISON AU RÉCEPTEUR DESTINÉES À ÊTRE UTILISÉES DANS DES VECTEURS POUR DÉLIVRER DES BACTÉRIES
Abstract
(EN)
The present disclosure relates generally to bacterial delivery vehicles for use in efficient transfer of a desired payload into a target bacterial cell. More specifically, the present disclosure relates to bacterial delivery vehicles with desired host ranges based on the presence of a chimeric receptor binding protein (RBP) composed of a fusion between the N-terminal region of a RBP derived from a lambda-like bacteriophage and the C-terminal region of a different RBP.
(FR)
Vecteurs pour délivrer des bactéries destinés à être utilisés pour un transfert efficace d'une charge utile souhaitée dans une cellule bactérienne cible. Plus particulièrement, la présente invention concerne des vecteurs pour délivrer des bactéries ayant des plages d'hôte souhaitées sur la base de la présence d'une protéine de liaison au récepteur chimérique (RBP) composée d'une fusion entre l'extrémité N-terminale d'une RBP dérivée d'un bactériophage du type lambda et de l'extrémité C-terminale d'un RBP différent.
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