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1. WO2020108881 - AQUEOUS COMPOSITION, IN PARTICULAR FOR TREATING MUCOSA AND/OR WOUNDS

Publication Number WO/2020/108881
Publication Date 04.06.2020
International Application No. PCT/EP2019/078876
International Filing Date 23.10.2019
IPC
A61K 9/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
A61K 9/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
08Solutions
A61K 31/53 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
53having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
A61K 47/10 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen
10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols ; Poloxamers; PEG/POE alkyl ethers
A61K 47/26 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/34 2017.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
CPC
A61K 31/53
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
53having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
A61K 47/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
08containing oxygen, ; e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
10Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
A61K 47/26
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
A61K 47/32
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
32Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers ; , poly(meth)acrylates, or polyvinyl pyrrolidone
A61K 47/34
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
34Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
A61K 9/0014
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
0012Galenical forms characterised by the site of application
0014Skin, i.e. galenical aspects of topical compositions
Applicants
  • B. BRAUN MELSUNGEN AG [DE]/[DE]
Inventors
  • ARNDT, Andreas
  • DÜCK, Natalie
  • KURZ, Michael
Agents
  • PATENTANWÄLTE RUFF, WILHELM, BEIER, DAUSTER & PARTNER MBB
Priority Data
10 2018 220 631.729.11.2018DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) WÄSSRIGE ZUSAMMENSETZUNG, INSBESONDERE ZUR BEHANDLUNG VON SCHLEIMHAUT UND/ODER WUNDEN
(EN) AQUEOUS COMPOSITION, IN PARTICULAR FOR TREATING MUCOSA AND/OR WOUNDS
(FR) COMPOSITION AQUEUSE, EN PARTICULIER POUR TRAITER UNE MUQUEUSE ET/OU DES PLAIES
Abstract
(DE)
Die Erfindung betrifft eine Wässrige Zusammensetzung, insbesondere zur Behandlung von Wunden, aufweisend - eine Dihydrotriazinverbindung der nachstehenden allgemeinen Formel I, wobei R1 (i) eine Phenylgruppe oder eine Phenylalkylgruppe, von denen jede optional mit 1bis 3 Substituenten, ausgewählt aus der Gruppe bestehend aus C1-6-Alkoxygruppe, Hydroxygruppe, einem Halogenatom, C1-6-Halogenalkylgruppe, C1-6-Alkylgruppe, einer Sulfonamidogruppe und C1-6-Halogenalkoxygruppe, substituiert ist, (ii) eine Naphthylgruppe oder eine Naphthylalkylgruppe, (iii) eine heterocyclische Gruppe, eine heterocyclische Alkylgruppe oder eine heterocyclische Aminoalkylgruppe, (iv) eine Alkylgruppe mit 1 bis 16 Kohlenstoffatomen oder (v) eine Cycloalkylgruppe oder eine Cycloalkyl-alkylgruppe bedeutet, R1' ein Wasserstoffatom, das an Position 1 oder 3 des Dihydrotriazinrings an das Stickstoffatom gebunden ist, bedeutet, R2 und R3 unabhängig voneinander ein Wasserstoffatom oder eine Methylgruppe bedeuten, R4 eine Alkylgruppe mit 7 bis 16 Kohlenstoffatomen bedeutet und die Strichlinie angibt, dass die Stellung einer Doppelbindung entweder zwischen den Positionen 1 und 2 oder zwischen den Positionen 2 und 3 des Dihydrotriazinrings liegt, oder ein Tautomer davon oder ein Salz davon und ein Tensid.
(EN)
The invention relates to an aqueous composition, in particular for treating wounds, having: a dihydrotriazine compound of the following general formula I, where R1 represents (i) a phenyl group or a phenylalkyl group, each of which is optionally substituted with 1 to 3 substituents, selected from a group consisting of the C1-6-alkoxy group, the hydroxy group, a halogen atom, the C1-6-alkyl halide group, the C1-6-alkyl group, a sulfonamido group and the C1-6-alkoxy halide group, (ii) a naphthyl group or a naphthyl alkyl group, (iii) a heterocyclic group, a heterocyclic alkyl group or a heterocyclic aminoalkyl group, (iv) an alkyl group with 1 to 16 carbon atoms or (v) a cycloalkyl group or a cycloalkyl-alkyl group, R1' represents a hydrogen atom, bonded with the nitrogen atom at position 1 or 3 of the dihydrotriazine ring, R2 and R3, independently of one another, represent a hydrogen atom or a methyl group, R4 represents an alkyl group with 7 to 16 carbon atoms, and the dashed line indicates that the position of a double bond is either between positions 1 and 2 or positions 2 and 3 of the dihydrotriazine ring; or having a tautomer of said composition, or a salt thereof, and a surfactant.
(FR)
L'invention concerne une composition aqueuse, en particulier pour traiter des plaies, comprenant : un composé dihydrotriazine représenté par la formule générale I, dans laquelle R1 représente (i) un groupe phényle ou un groupe phénylalkyle, pouvant chacun être substitué éventuellement par 1 à 3 substituants choisis dans le groupe constitué par un groupe alcoxy en C1-6, un groupe hydroxy, un atome d'halogène, un groupe halogénoalkyle en C1-6, un groupe alkyle en C1-6, un groupe sulfonamide et un groupe halogénoalcoxy en C1-6, (ii) un groupe naphtyle ou un groupe naphtylalkyle, (iii) un groupe hétérocyclique, un groupe alkyle hétérocyclique ou un groupe aminoalkyle hétérocyclique, (iv) un groupe alkyle comportant 1 à 16 atomes de carbone ou (v) un groupe cycloalkyle ou un groupe cycloalkyl-alkyle, R1' représente un atome d'hydrogène qui est lié à l'atome d'azote en position 1 ou 3 du cycle dihydrotriazine, R2 et R3 représentent indépendamment un atome d'hydrogène ou un groupe méthyle, R4 représente un groupe alkyle comportant 7 à 16 atomes de carbone et la ligne pointillée indique que l'emplacement d'une double liaison est entre les positions 1 et 2 ou entre les positions 2 et 3 du cycle dihydrotriazine, ou un tautomère ou un sel de ce composé ; ainsi qu'un tensioactif.
Also published as
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