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1. WO2020108664 - STEPPED BIOLOGICAL CHIP AND GENE SEQUENCING DEVICE FOR TESTING SAME

Publication Number WO/2020/108664
Publication Date 04.06.2020
International Application No. PCT/CN2020/070194
International Filing Date 03.01.2020
IPC
G01N 21/64 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
21Investigating or analysing materials by the use of optical means, i.e. using infra-red, visible or ultra-violet light
62Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
63optically excited
64Fluorescence; Phosphorescence
C12M 1/34 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1Apparatus for enzymology or microbiology
34Measuring or testing with condition measuring or sensing means, e.g. colony counters
B01L 3/00 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
CPC
B01L 2300/0627
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
06Auxiliary integrated devices, integrated components
0627Sensor or part of a sensor is integrated
B01L 2300/0654
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
06Auxiliary integrated devices, integrated components
0627Sensor or part of a sensor is integrated
0654Lenses; Optical fibres
B01L 2300/168
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
2300Additional constructional details
16Surface properties and coatings
168Specific optical properties, e.g. reflective coatings
B01L 3/5027
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
3Containers or dishes for laboratory use, e.g. laboratory glassware
50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
502with fluid transport, e.g. in multi-compartment structures
5027by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
C12Q 1/6869
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS
1Measuring or testing processes involving enzymes, nucleic acids or microorganisms
68involving nucleic acids
6869Methods for sequencing
Applicants
  • 茂莱(南京)仪器有限公司 MOONLIGHT (NANJING) INSTRUMENT CO., LTD. [CN]/[CN]
Inventors
  • 余美群 YU, Meiqun
  • 周威 ZHOU, Wei
Agents
  • 南京苏高专利商标事务所(普通合伙) NANJING SUGAO PATENT AND TRADEMARK FIRM (ORDINARY PARTNERSHIP)
Priority Data
201811427102.627.11.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) STEPPED BIOLOGICAL CHIP AND GENE SEQUENCING DEVICE FOR TESTING SAME
(FR) PUCE BIOLOGIQUE ÉTAGÉE ET DISPOSITIF DE SÉQUENÇAGE DE GÈNES POUR TESTER CELLE-CI
(ZH) 一种台阶式生物芯片以及用于检测该生物芯片的基因测序装置
Abstract
(EN)
A stepped biological chip and a gene sequencing device for testing same. The stepped biological chip comprises substrates and small fluorescent balls carrying biological information arranged on the top of the substrates, and the heights of the center point of adjacent small fluorescent balls from a substrate bottom edge A are incremented or decremented by equal value. The gene sequencing device comprises a chip placing platform, the stepped biological chip, and a microscope objective lens placed above the chip placing platform and an illumination light source irradiated on the stepped biological chip at a certain angle of incidence.
(FR)
L'invention concerne une puce biologique étagée et un dispositif de séquençage de gènes pour tester celle-ci. La puce biologique étagée comprend des substrats et de petites billes fluorescentes portant des informations biologiques disposées sur le dessus des substrats, et les hauteurs du point central de petites billes fluorescentes adjacentes à partir d'un bord inférieur de substrat A sont incrémentées ou décrémentées d'une valeur égale. Le dispositif de séquençage de gènes comprend une plateforme de placement de puce, la puce biologique étagée et une lentille d'objectif de microscope placée au-dessus de la plateforme de placement de puce et une source de lumière d'éclairage irradiée sur la puce biologique étagée selon un certain angle d'incidence.
(ZH)
一种台阶式生物芯片及用于检测该生物芯片的基因测序装置。该台阶式生物芯片包括基底以及位于基底顶端携带有生物信息的荧光小球,相邻荧光小球中心点距基底底边A的高度为等数值递增或递减。该基因测序装置包括芯片放置平台、台阶式生物芯片、位于芯片放置平台上方的显微物镜以及以一定入射角度照射在台阶式生物芯片上的照明光源。
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