Processing

Please wait...

Settings

Settings

Goto Application

1. WO2020108659 - NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF

Publication Number WO/2020/108659
Publication Date 04.06.2020
International Application No. PCT/CN2019/122459
International Filing Date 02.12.2019
IPC
C07D 487/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
A61K 31/519
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519ortho- or peri-condensed with heterocyclic rings
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
C07D 487/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
487Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • 上海医药集团股份有限公司 SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. [CN]/[CN]
Inventors
  • 李迪 LI, Di
  • 段灵峻 DUAN, Lingjun
  • 郑体旭 ZHENG, Tixu
  • 王阳 WANG, Yang
  • 金凯军 JIN, Kaijun
  • 苏威 SU, Wei
  • 洪媛 HONG, Yuan
  • 徐佳 XU, Jia
  • 夏广新 XIA, Guangxin
  • 柯樱 KE, Ying
Agents
  • 上海弼兴律师事务所 SHANGHAI BESHINING LAW OFFICE
Priority Data
201811455353.530.11.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND COMPOSITION THEREOF, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF
(FR) COMPOSÉ HÉTÉROCYCLIQUE CONTENANT DE L'AZOTE, COMPOSITION À BASE DE CELUI-CI, PROCÉDÉ DE PRÉPARATION CORRESPONDANT ET UTILISATION ASSOCIÉE
(ZH) 含氮杂环类化合物及其组合物、制备方法和应用
Abstract
(EN)
Disclosed by the present invention are a nitrogen-containing heterocyclic compound, and a composition thereof, a preparation method therefor and an application thereof. The structure of the nitrogen-containing heterocyclic compound according to the present invention is shown in Formula I. The nitrogen-containing heterocyclic compound according to the present invention or a pharmaceutically acceptable salt thereof has better inhibitory activity on p38 protein kinase and/or higher bioavailability. In addition, the preparation method is simple.
(FR)
L'invention concerne un composé hétérocyclique contenant de l'azote, une composition à base de celui-ci, un procédé de préparation correspondant et une utilisation associée. La structure du composé hétérocyclique contenant de l'azote selon la présente invention est représentée par la formule I. Le composé hétérocyclique contenant de l'azote selon la présente invention ou un sel pharmaceutiquement acceptable de celui-ci présente une meilleure activité inhibitrice sur la protéine kinase p38 et/ou une biodisponibilité supérieure. De plus, le procédé de préparation est simple.
(ZH)
本发明公开了一种含氮杂环类化合物及其组合物、制备方法和应用。本发明的含氮杂环类化合物结构如式I所示。本发明的含氮杂环类化合物或其药学上可接受的盐对p38蛋白激酶具有较好的抑制活性和/或较高的生物利用度。此外,该制备方法简单。
Latest bibliographic data on file with the International Bureau