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1. WO2020108621 - CD40 ANTIBODY PHARMACEUTICAL COMPOSITION AND USE THEREOF

Publication Number WO/2020/108621
Publication Date 04.06.2020
International Application No. PCT/CN2019/121985
International Filing Date 29.11.2019
IPC
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
A61K 39/395 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A61P 35/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
CPC
A61K 39/395
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
395Antibodies
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
C07K 16/28
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
Applicants
  • 江苏恒瑞医药股份有限公司 JIANGSU HENGRUI MEDICINE CO., LTD. [CN]/[CN]
  • 上海恒瑞医药有限公司 SHANGHAI HENGRUI PHARMACEUTICAL CO., LTD. [CN]/[CN]
Inventors
  • 杨健健 YANG, Jianjian
  • 李皓 LI, Hao
  • 刘洵 LIU, Xun
  • 蒋家骅 JIANG, Jiahua
Agents
  • 上海弼兴律师事务所 SHANGHAI BESHINING LAW OFFICE
Priority Data
201811448238.530.11.2018CN
Publication Language Chinese (ZH)
Filing Language Chinese (ZH)
Designated States
Title
(EN) CD40 ANTIBODY PHARMACEUTICAL COMPOSITION AND USE THEREOF
(FR) COMPOSITION PHARMACEUTIQUE D'ANTICORPS ANTI-CD40 ET SON UTILISATION
(ZH) 一种CD40抗体药物组合物及其用途
Abstract
(EN)
The present invention provides a pharmaceutical composition comprising a CD40 antibody or an antigen-binding fragment thereof and an acetic acid-sodium acetate buffer solution, and a use thereof. The pharmaceutical composition may further contain sugar, a non-ionic surfactant, and other excipients. The pharmaceutical composition of the present invention shows good antibody stability.
(FR)
La présente invention concerne une composition pharmaceutique comprenant un anticorps anti-CD40 ou un fragment de liaison à l'antigène de celui-ci et une solution tampon d'acide acétique-acétate de sodium, ainsi qu'une utilisation associée. La composition pharmaceutique peut comprendre également un sucre, un tensioactif non ionique ainsi que d'autres excipients. La composition pharmaceutique selon la présente invention a une bonne stabilité d'anticorps.
(ZH)
本发明提供了一种包含CD40抗体或其抗原结合片段以及醋酸-醋酸钠缓冲液的药物组合物及其用途。所述药物组合物还可含有糖、非离子型表面活性剂和其他辅料。本发明的药物组合物展现了良好的抗体稳定性。
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